Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

por Edmond M. Linossi, Kunlun Li, Gianluca Veggiani, Cyrus Tan, Farhad Dehkhoda, Colin Hockings, Dale J. Calleja, Narelle Keating, Rebecca Feltham, Andrew J. Brooks, Shawn S. Li, Sachdev S. Sidhu, Jeffrey J. Babon, Nadia J. Kershaw, Sandra E. Nicholson
Publicado 2021

Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex

por Luke F. Pennington, Pascal Gasser, Silke Kleinboelting, Chensong Zhang, Georgios Skiniotis, Alexander Eggel, Theodore S. Jardetzky
Publicado 2021

Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits

por Marion Patxot, Daniel Trejo Banos, Athanasios Kousathanas, Etienne J. Orliac, Sven E. Ojavee, Gerhard Moser, Alexander Holloway, Julia Sidorenko, Zoltan Kutalik, Reedik Mägi, Peter M. Visscher, Lars Rönnegård, Matthew R. Robinson
Publicado 2021

Emergence of a neopelagic community through the establishment of coastal species on the high seas

por Linsey E. Haram, James T. Carlton, Luca Centurioni, Mary Crowley, Jan Hafner, Nikolai Maximenko, Cathryn Clarke Murray, Andrey Y. Shcherbina, Verena Hormann, Cynthia Wright, Gregory M. Ruiz
Publicado 2021

Thermochemical anomalies in the upper mantle control Gakkel Ridge accretion

por John M. O’Connor, Wilfried Jokat, Peter J. Michael, Mechita C. Schmidt-Aursch, Daniel P. Miggins, Anthony A. P. Koppers
Publicado 2021

Engineering of a fluorescent chemogenetic reporter with tunable color for advanced live-cell imaging

por Hela Benaissa, Karim Ounoughi, Isabelle Aujard, Evelyne Fischer, Rosette Goïame, Julie Nguyen, Alison G. Tebo, Chenge Li, Thomas Le Saux, Giulia Bertolin, Marc Tramier, Lydia Danglot, Nicolas Pietrancosta, Xavier Morin, Ludovic Jullien, Arnaud Gautier
Publicado 2021

Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer

por Meng Wang, Yue Li, Yunyun Xiao, Muwen Yang, Jinxin Chen, Yunting Jian, Xin Chen, Dongni Shi, Xiangfu Chen, Ying Ouyang, Lingzhi Kong, Xinjian Huang, Jiewen Bai, Chuyong Lin, Libing Song
Publicado 2021

Publisher Correction: Subnanometer high-entropy alloy nanowires enable remarkable hydrogen oxidation catalysis

por Changhong Zhan, Yong Xu, Lingzheng Bu, Huaze Zhu, Yonggang Feng, Tang Yang, Ying Zhang, Zhiqing Yang, Bolong Huang, Qi Shao, Xiaoqing Huang
Publicado 2021

RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis

por Jingchun Du, Yougui Xiang, Hua Liu, Shuzhen Liu, Ashwani Kumar, Chao Xing, Zhigao Wang
Publicado 2021

Revealing nano-scale lattice distortions in implanted material with 3D Bragg ptychography

por Peng Li, Nicholas W. Phillips, Steven Leake, Marc Allain, Felix Hofmann, Virginie Chamard
Publicado 2021

Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors

por Wen Hao Neo, Yiran Meng, Alba Rodriguez-Meira, Muhammad Z. H. Fadlullah, Christopher A. G. Booth, Emanuele Azzoni, Supat Thongjuea, Marella F. T. R. de Bruijn, Sten Eirik W. Jacobsen, Adam J. Mead, Georges Lacaud
Publicado 2021

Cilia locally synthesize proteins to sustain their ultrastructure and functions

por Kai Hao, Yawen Chen, Xiumin Yan, Xueliang Zhu
Publicado 2021

Two-colour single-molecule photoinduced electron transfer fluorescence imaging microscopy of chaperone dynamics

por Jonathan Schubert, Andrea Schulze, Chrisostomos Prodromou, Hannes Neuweiler
Publicado 2021

GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity

por Yumeng Peng, Qiang Zeng, Luming Wan, Enhao Ma, Huilong Li, Xiaopan Yang, Yanhong Zhang, Linfei Huang, Haotian Lin, Jiangyue Feng, Yixin Xu, Jingfei Li, Muyi Liu, Jing Liu, Changqin Lin, Zhiwei Sun, Gong Cheng, Xuemiao Zhang, Jialong Liu, Dongrui Li, Meng Wei, Yunhai Mo, Xuetao Mu, Xiaowei Deng, Dandan Zhang, Siqing Dong, Hanqing Huang, Yi Fang, Qi Gao, Xiaoli Yang, Feixiang Wu, Hui Zhong, Congwen Wei
Publicado 2021

SPEN is required for Xist upregulation during initiation of X chromosome inactivation

por Teresa Robert-Finestra, Beatrice F. Tan, Hegias Mira-Bontenbal, Erika Timmers, Cristina Gontan, Sarra Merzouk, Benedetto Daniele Giaimo, François Dossin, Wilfred F. J. van IJcken, John W. M. Martens, Tilman Borggrefe, Edith Heard, Joost Gribnau
Publicado 2021

Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single‐cell transcriptomics

por Stephan M. Tirier, Jan-Philipp Mallm, Simon Steiger, Alexandra M. Poos, Mohamed H. S. Awwad, Nicola Giesen, Nicola Casiraghi, Hana Susak, Katharina Bauer, Anja Baumann, Lukas John, Anja Seckinger, Dirk Hose, Carsten Müller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Michael Hundemer, Niels Weinhold, Marc S. Raab, Karsten Rippe
Publicado 2021

Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα

por Ozren Stojanović, Jordi Altirriba, Dorothée Rigo, Martina Spiljar, Emilien Evrard, Benedek Roska, Salvatore Fabbiano, Nicola Zamboni, Pierre Maechler, Françoise Rohner-Jeanrenaud, Mirko Trajkovski
Publicado 2021

Short-read and long-read RNA sequencing of mouse hematopoietic stem cells at bulk and single-cell levels

por Xiuran Zheng, Dan Zhang, Mengying Xu, Wanqin Zeng, Ran Zhou, Yiming Zhang, Chao Tang, Li Chen, Lu Chen, Jing-wen Lin
Publicado 2021

COVID-19 Flow-Maps an open geographic information system on COVID-19 and human mobility for Spain

por Miguel Ponce-de-Leon, Javier del Valle, José María Fernandez, Marc Bernardo, Davide Cirillo, Jon Sanchez-Valle, Matthew Smith, Salvador Capella-Gutierrez, Tania Gullón, Alfonso Valencia
Publicado 2021

Insights into the changes in the proteome of Alzheimer disease elucidated by a meta-analysis

por Hazal Haytural, Rui Benfeitas, Sophia Schedin-Weiss, Erika Bereczki, Melinda Rezeli, Richard D. Unwin, Xusheng Wang, Eric B. Dammer, Erik C. B. Johnson, Nicholas T. Seyfried, Bengt Winblad, Betty M. Tijms, Pieter Jelle Visser, Susanne Frykman, Lars O. Tjernberg
Publicado 2021