Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity

por Maura Garofalo, Luca Piccoli, Margherita Romeo, Maria Monica Barzago, Sara Ravasio, Mathilde Foglierini, Milos Matkovic, Jacopo Sgrignani, Raoul De Gasparo, Marco Prunotto, Luca Varani, Luisa Diomede, Olivier Michielin, Antonio Lanzavecchia, Andrea Cavalli
Publicado 2021

COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system

por Susanne Rysz, Jonathan Al-Saadi, Anna Sjöström, Maria Farm, Francesca Campoccia Jalde, Michael Plattén, Helen Eriksson, Margareta Klein, Roberto Vargas-Paris, Sven Nyrén, Goran Abdula, Russell Ouellette, Tobias Granberg, Malin Jonsson Fagerlund, Johan Lundberg
Publicado 2021

Living fabrication of functional semi-interpenetrating polymeric materials

por Zhuojun Dai, Xiaoyu Yang, Feilun Wu, Lihua Wang, Kun Xiang, Pengcheng Li, Qingqing Lv, Jinhui Tang, Anders Dohlman, Lei Dai, Xiling Shen, Lingchong You
Publicado 2021

Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD

por Joel Fauser, Burak Gulen, Vivian Pogenberg, Christian Pett, Danial Pourjafar-Dehkordi, Christoph Krisp, Dorothea Höpfner, Gesa König, Hartmut Schlüter, Matthias J. Feige, Martin Zacharias, Christian Hedberg, Aymelt Itzen
Publicado 2021

Mitochondrial function controls intestinal epithelial stemness and proliferation

por Emanuel Berger, Eva Rath, Detian Yuan, Nadine Waldschmitt, Sevana Khaloian, Michael Allgäuer, Ori Staszewski, Elena M. Lobner, Theresa Schöttl, Pieter Giesbertz, Olivia I. Coleman, Marco Prinz, Achim Weber, Markus Gerhard, Martin Klingenspor, Klaus-Peter Janssen, Mathias Heikenwalder, Dirk Haller
Publicado 2016

PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis

por Ji Liang, Ruixiu Cao, Yajuan Zhang, Yan Xia, Yanhua Zheng, Xinjian Li, Liwei Wang, Weiwei Yang, Zhimin Lu
Publicado 2016

Bias free multiobjective active learning for materials design and discovery

por Kevin Maik Jablonka, Giriprasad Melpatti Jothiappan, Shefang Wang, Berend Smit, Brian Yoo
Publicado 2021

Genomic profile of advanced breast cancer in circulating tumour DNA

por Belinda Kingston, Rosalind J. Cutts, Hannah Bye, Matthew Beaney, Giselle Walsh-Crestani, Sarah Hrebien, Claire Swift, Lucy S. Kilburn, Sarah Kernaghan, Laura Moretti, Katie Wilkinson, Andrew M. Wardley, Iain R. Macpherson, Richard D. Baird, Rebecca Roylance, Jorge S. Reis-Filho, Michael Hubank, Iris Faull, Kimberly C. Banks, Richard B. Lanman, Isaac Garcia-Murillas, Judith M. Bliss, Alistair Ring, Nicholas C. Turner
Publicado 2021

Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel

por Ying Yin, Mengyu Wu, Allen L. Hsu, William F. Borschel, Mario J. Borgnia, Gabriel C. Lander, Seok-Yong Lee
Publicado 2019

Mixed-state electron ptychography enables sub-angstrom resolution imaging with picometer precision at low dose

por Zhen Chen, Michal Odstrcil, Yi Jiang, Yimo Han, Ming-Hui Chiu, Lain-Jong Li, David A. Muller
Publicado 2020

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

por Arjun S. Adhikari, Darshan V. Trivedi, Saswata S. Sarkar, Dan Song, Kristina B. Kooiker, Daniel Bernstein, James A. Spudich, Kathleen M. Ruppel
Publicado 2019

Stretchable chiral pockets for palladium-catalyzed highly chemo- and enantioselective allenylation

por Yuchen Zhang, Xue Zhang, Shengming Ma
Publicado 2021

β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity

por Luiz F. Barella, Mario Rossi, Sai P. Pydi, Jaroslawna Meister, Shanu Jain, Yinghong Cui, Oksana Gavrilova, Gianluca Fulgenzi, Lino Tessarollo, Jürgen Wess
Publicado 2021

A single atom change turns insulating saturated wires into molecular conductors

por Xiaoping Chen, Bernhard Kretz, Francis Adoah, Cameron Nickle, Xiao Chi, Xiaojiang Yu, Enrique del Barco, Damien Thompson, David A. Egger, Christian A. Nijhuis
Publicado 2021

Layered-rocksalt intergrown cathode for high-capacity zero-strain battery operation

por Ning Li, Meiling Sun, Wang Hay Kan, Zengqing Zhuo, Sooyeon Hwang, Sara E. Renfrew, Maxim Avdeev, Ashfia Huq, Bryan D. McCloskey, Dong Su, Wanli Yang, Wei Tong
Publicado 2021

Microbial reduction of metal-organic frameworks enables synergistic chromium removal

por Sarah K. Springthorpe, Christopher M. Dundas, Benjamin K. Keitz
Publicado 2019

Procr-expressing progenitor cells are responsible for murine ovulatory rupture repair of ovarian surface epithelium

por Jingqiang Wang, Daisong Wang, Kun Chu, Wen Li, Yi Arial Zeng
Publicado 2019

Network-based in silico drug efficacy screening

por Emre Guney, Jörg Menche, Marc Vidal, Albert-László Barábasi
Publicado 2016

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

por Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms, Anna V. Protasio, Marta Seczynska, Daniil M. Prigozhin, Anna Albecka, Jane Wagstaff, James C. Williamson, Stefan M. V. Freund, Paul J. Lehner, Yorgo Modis
Publicado 2020

VEGA is an interpretable generative model for inferring biological network activity in single-cell transcriptomics

por Lucas Seninge, Ioannis Anastopoulos, Hongxu Ding, Joshua Stuart
Publicado 2021