Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease

por Julia Benkert, Simon Hess, Shoumik Roy, Dayne Beccano-Kelly, Nicole Wiederspohn, Johanna Duda, Carsten Simons, Komal Patil, Aisylu Gaifullina, Nadja Mannal, Elena Dragicevic, Desirée Spaich, Sonja Müller, Julia Nemeth, Helene Hollmann, Nora Deuter, Yassine Mousba, Christian Kubisch, Christina Poetschke, Joerg Striessnig, Olaf Pongs, Toni Schneider, Richard Wade-Martins, Sandip Patel, Rosanna Parlato, Tobias Frank, Peter Kloppenburg, Birgit Liss
Publicado 2019

Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice

por Julia Duerr, Dominik H. W. Leitz, Magdalena Szczygiel, Dmytro Dvornikov, Simon G. Fraumann, Clemens Kreutz, Piotr K. Zadora, Ayça Seyhan Agircan, Philip Konietzke, Theresa A. Engelmann, Jan Hegermann, Surafel Mulugeta, Hiroshi Kawabe, Lars Knudsen, Matthias Ochs, Daniela Rotin, Thomas Muley, Michael Kreuter, Felix J. F. Herth, Mark O. Wielpütz, Michael F. Beers, Ursula Klingmüller, Marcus A. Mall
Publicado 2020

Radar vision in the mapping of forest biodiversity from space

por Soyeon Bae, Shaun R. Levick, Lea Heidrich, Paul Magdon, Benjamin F. Leutner, Stephan Wöllauer, Alla Serebryanyk, Thomas Nauss, Peter Krzystek, Martin M. Gossner, Peter Schall, Christoph Heibl, Claus Bässler, Inken Doerfler, Ernst-Detlef Schulze, Franz-Sebastian Krah, Heike Culmsee, Kirsten Jung, Marco Heurich, Markus Fischer, Sebastian Seibold, Simon Thorn, Tobias Gerlach, Torsten Hothorn, Wolfgang W. Weisser, Jörg Müller
Publicado 2019

Earliest Olduvai hominins exploited unstable environments ~ 2 million years ago

por Julio Mercader, Pam Akuku, Nicole Boivin, Revocatus Bugumba, Pastory Bushozi, Alfredo Camacho, Tristan Carter, Siobhán Clarke, Arturo Cueva-Temprana, Paul Durkin, Julien Favreau, Kelvin Fella, Simon Haberle, Stephen Hubbard, Jamie Inwood, Makarius Itambu, Samson Koromo, Patrick Lee, Abdallah Mohammed, Aloyce Mwambwiga, Lucas Olesilau, Robert Patalano, Patrick Roberts, Susan Rule, Palmira Saladie, Gunnar Siljedal, María Soto, Jonathan Umbsaar, Michael Petraglia
Publicado 2021

The genetic architecture of floral traits in the woody plant Prunus mume

por Qixiang Zhang, He Zhang, Lidan Sun, Guangyi Fan, Meixia Ye, Libo Jiang, Xin Liu, Kaifeng Ma, Chengcheng Shi, Fei Bao, Rui Guan, Yu Han, Yuanyuan Fu, Huitang Pan, Zhaozhe Chen, Liangwei Li, Jia Wang, Meiqi Lv, Tangchun Zheng, Cunquan Yuan, Yuzhen Zhou, Simon Ming-Yuen Lee, Xiaolan Yan, Xun Xu, Rongling Wu, Wenbin Chen, Tangren Cheng
Publicado 2018

Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice

por Iain W. McNae, James Kinkead, Divya Malik, Li-Hsuan Yen, Martin K. Walker, Chris Swain, Scott P. Webster, Nick Gray, Peter M. Fernandes, Elmarie Myburgh, Elizabeth A. Blackburn, Ryan Ritchie, Carol Austin, Martin A. Wear, Adrian J. Highton, Andrew J. Keats, Antonio Vong, Jacqueline Dornan, Jeremy C. Mottram, Paul A. M. Michels, Simon Pettit, Malcolm D. Walkinshaw
Publicado 2021

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

por Hamid Nikbakht, Eshini Panditharatna, Leonie G. Mikael, Rui Li, Tenzin Gayden, Matthew Osmond, Cheng-Ying Ho, Madhuri Kambhampati, Eugene I. Hwang, Damien Faury, Alan Siu, Simon Papillon-Cavanagh, Denise Bechet, Keith L. Ligon, Benjamin Ellezam, Wendy J. Ingram, Caedyn Stinson, Andrew S. Moore, Katherine E. Warren, Jason Karamchandani, Roger J. Packer, Nada Jabado, Jacek Majewski, Javad Nazarian
Publicado 2016

A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

por Marta Compte, Seandean Lykke Harwood, Ines G. Muñoz, Rocio Navarro, Manuela Zonca, Gema Perez-Chacon, Ainhoa Erce-Llamazares, Nekane Merino, Antonio Tapia-Galisteo, Angel M. Cuesta, Kasper Mikkelsen, Eduardo Caleiras, Natalia Nuñez-Prado, M. Angela Aznar, Simon Lykkemark, Jorge Martínez-Torrecuadrada, Ignacio Melero, Francisco J. Blanco, Jorge Bernardino de la Serna, Juan M. Zapata, Laura Sanz, Luis Alvarez-Vallina
Publicado 2018

SARS-CoV-2 infection and replication in human gastric organoids

por Giovanni Giuseppe Giobbe, Francesco Bonfante, Brendan C. Jones, Onelia Gagliano, Camilla Luni, Elisa Zambaiti, Silvia Perin, Cecilia Laterza, Georg Busslinger, Hannah Stuart, Matteo Pagliari, Alessio Bortolami, Eva Mazzetto, Anna Manfredi, Chiara Colantuono, Lucio Di Filippo, Alessandro Filippo Pellegata, Valentina Panzarin, Nikhil Thapar, Vivian Sze Wing Li, Simon Eaton, Davide Cacchiarelli, Hans Clevers, Nicola Elvassore, Paolo De Coppi
Publicado 2021

A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters

por Phanramphoei N. Frantz, Aleksandr Barinov, Claude Ruffié, Chantal Combredet, Valérie Najburg, Guilherme Dias de Melo, Florence Larrous, Lauriane Kergoat, Samaporn Teeravechyan, Anan Jongkaewwattana, Emmanuelle Billon-Denis, Jean-Nicolas Tournier, Matthieu Prot, Laurine Levillayer, Laurine Conquet, Xavier Montagutelli, Magali Tichit, David Hardy, Priyanka Fernandes, Hélène Strick-Marchand, James Di Santo, Etienne Simon-Lorière, Hervé Bourhy, Frédéric Tangy
Publicado 2021

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease

por Paul K. Potter, Michael R. Bowl, Prashanthini Jeyarajan, Laura Wisby, Andrew Blease, Michelle E. Goldsworthy, Michelle M. Simon, Simon Greenaway, Vincent Michel, Alun Barnard, Carlos Aguilar, Thomas Agnew, Gareth Banks, Andrew Blake, Lauren Chessum, Joanne Dorning, Sara Falcone, Laurence Goosey, Shelley Harris, Andy Haynes, Ines Heise, Rosie Hillier, Tertius Hough, Angela Hoslin, Marie Hutchison, Ruairidh King, Saumya Kumar, Heena V. Lad, Gemma Law, Robert E. MacLaren, Susan Morse, Thomas Nicol, Andrew Parker, Karen Pickford, Siddharth Sethi, Becky Starbuck, Femke Stelma, Michael Cheeseman, Sally H. Cross, Russell G. Foster, Ian J. Jackson, Stuart N. Peirson, Rajesh V. Thakker, Tonia Vincent, Cheryl Scudamore, Sara Wells, Aziz El-Amraoui, Christine Petit, Abraham Acevedo-Arozena, Patrick M. Nolan, Roger Cox, Anne-Marie Mallon, Steve D. M. Brown
Publicado 2016

Fonio millet genome unlocks African orphan crop diversity for agriculture in a changing climate

por Michael Abrouk, Hanin Ibrahim Ahmed, Philippe Cubry, Denisa Šimoníková, Stéphane Cauet, Yveline Pailles, Jan Bettgenhaeuser, Liubov Gapa, Nora Scarcelli, Marie Couderc, Leila Zekraoui, Nagarajan Kathiresan, Jana Čížková, Eva Hřibová, Jaroslav Doležel, Sandrine Arribat, Hélène Bergès, Jan J. Wieringa, Mathieu Gueye, Ndjido A. Kane, Christian Leclerc, Sandrine Causse, Sylvie Vancoppenolle, Claire Billot, Thomas Wicker, Yves Vigouroux, Adeline Barnaud, Simon G. Krattinger
Publicado 2020

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

por Christian K. Holm, Stine H. Rahbek, Hans Henrik Gad, Rasmus O. Bak, Martin R. Jakobsen, Zhaozaho Jiang, Anne Louise Hansen, Simon K. Jensen, Chenglong Sun, Martin K. Thomsen, Anders Laustsen, Camilla G. Nielsen, Kasper Severinsen, Yingluo Xiong, Dara L. Burdette, Veit Hornung, Robert Jan Lebbink, Mogens Duch, Katherine A. Fitzgerald, Shervin Bahrami, Jakob Giehm Mikkelsen, Rune Hartmann, Søren R. Paludan
Publicado 2016

Publisher Correction: Critical Southern Ocean climate model biases traced to atmospheric model cloud errors

por Patrick Hyder, John M. Edwards, Richard P. Allan, Helene T. Hewitt, Thomas J. Bracegirdle, Jonathan M. Gregory, Richard A. Wood, Andrew J. S. Meijers, Jane Mulcahy, Paul Field, Kalli Furtado, Alejandro Bodas-Salcedo, Keith D. Williams, Dan Copsey, Simon A. Josey, Chunlei Liu, Chris D. Roberts, Claudio Sanchez, Jeff Ridley, Livia Thorpe, Steven C. Hardiman, Michael Mayer, David I. Berry, Stephen E. Belcher
Publicado 2018

A clinical transcriptome approach to patient stratification and therapy selection in acute myeloid leukemia

por T. Roderick Docking, Jeremy D. K. Parker, Martin Jädersten, Gerben Duns, Linda Chang, Jihong Jiang, Jessica A. Pilsworth, Lucas A. Swanson, Simon K. Chan, Readman Chiu, Ka Ming Nip, Samantha Mar, Angela Mo, Xuan Wang, Sergio Martinez-Høyer, Ryan J. Stubbins, Karen L. Mungall, Andrew J. Mungall, Richard A. Moore, Steven J. M. Jones, İnanç Birol, Marco A. Marra, Donna Hogge, Aly Karsan
Publicado 2021

Critical Southern Ocean climate model biases traced to atmospheric model cloud errors

por Patrick Hyder, John M. Edwards, Richard P. Allan, Helene T. Hewitt, Thomas J. Bracegirdle, Jonathan M. Gregory, Richard A. Wood, Andrew J. S. Meijers, Jane Mulcahy, Paul Field, Kalli Furtado, Alejandro Bodas-Salcedo, Keith D. Williams, Dan Copsey, Simon A. Josey, Chunlei Liu, Chris D. Roberts, Claudio Sanchez, Jeff Ridley, Livia Thorpe, Steven C. Hardiman, Michael Mayer, David I. Berry, Stephen E. Belcher
Publicado 2018

Dynamic and features of SARS-CoV-2 infection in Gabon

por Amandine Mveang Nzoghe, Guy-Stephan Padzys, Anicet Christel Maloupazoa Siawaya, Marisca Kandet Yattara, Marielle Leboueny, Rotimi Myrabelle Avome Houechenou, Eliode Cyrien Bongho, Cedrick Mba-Mezeme, Ofilia Mvoundza Ndjindji, Jean Claude Biteghe-Bi-Essone, Alain Boulende, Paulin N. Essone, Carene Anne Alene Ndong Sima, Ulysse Minkobame, Carinne Zang Eyi, Bénédicte Ndeboko, Alexandru Voloc, Jean-François Meye, Simon Ategbo, Joel Fleury Djoba Siawaya
Publicado 2021

Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance

por Baptiste Rode, Jian Shi, Naima Endesh, Mark J. Drinkhill, Peter J. Webster, Sabine J. Lotteau, Marc A. Bailey, Nadira Y. Yuldasheva, Melanie J. Ludlow, Richard M. Cubbon, Jing Li, T. Simon Futers, Lara Morley, Hannah J. Gaunt, Katarzyna Marszalek, Hema Viswambharan, Kevin Cuthbertson, Paul D. Baxter, Richard Foster, Piruthivi Sukumar, Andrew Weightman, Sarah C. Calaghan, Stephen B. Wheatcroft, Mark T. Kearney, David J. Beech
Publicado 2017

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis

por Sebastian Dütting, Frederique Gaits-Iacovoni, David Stegner, Michael Popp, Adrien Antkowiak, Judith M.M. van Eeuwijk, Paquita Nurden, Simon Stritt, Tobias Heib, Katja Aurbach, Oguzhan Angay, Deya Cherpokova, Niels Heinz, Ayesha A. Baig, Maximilian G. Gorelashvili, Frank Gerner, Katrin G. Heinze, Jerry Ware, Georg Krohne, Zaverio M. Ruggeri, Alan T. Nurden, Harald Schulze, Ute Modlich, Irina Pleines, Cord Brakebusch, Bernhard Nieswandt
Publicado 2017

The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions

por Thomas J. Littlejohns, Jo Holliday, Lorna M. Gibson, Steve Garratt, Niels Oesingmann, Fidel Alfaro-Almagro, Jimmy D. Bell, Chris Boultwood, Rory Collins, Megan C. Conroy, Nicola Crabtree, Nicola Doherty, Alejandro F. Frangi, Nicholas C. Harvey, Paul Leeson, Karla L. Miller, Stefan Neubauer, Steffen E. Petersen, Jonathan Sellors, Simon Sheard, Stephen M. Smith, Cathie L. M. Sudlow, Paul M. Matthews, Naomi E. Allen
Publicado 2020