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  1. 37641
    Stable and Highly Immunogenic MicroRNA-Targeted Single-Dose Live Attenuated Vaccine Candidate against Tick-Borne Encephalitis Constructed Using Genetic Backbone of Langat Virus
    “... preclinical evaluation of its neurovirulence in NHPs prior to entering clinical trials in humans. IMPORTANCE...”
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  2. 37642
    New Multidrug Efflux Inhibitors for Gram-Negative Bacteria
    “... concentrations contributes to clinically relevant multidrug resistance. Inhibition of active efflux potentiates...”
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  3. 37643
    Conservation and Divergence in the <italic toggle="yes">Candida</italic> Species Biofilm Matrix Mannan-Glucan Complex Structure, Function, and Genetic Control
    “..., and genetic approaches to explore a similar mechanism of resistance for the three most common clinically...”
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  4. 37644
    Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection
    “... could have far-reaching clinical benefits. US28 is one of the few viral genes that is expressed during...”
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  5. 37645
    High-Throughput Analysis of Gene Function in the Bacterial Predator <named-content content-type="genus-species">Bdellovibrio bacteriovorus</named-content>
    “.... bacteriovorus to kill harmful pathogens in the clinical setting. IMPORTANCE Bdellovibrio bacteriovorus is a...”
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  6. 37646
    Antibody-Based Therapy for Enterococcal Catheter-Associated Urinary Tract Infections
    “... clinical CAUTI, bloodstream, and gastrointestinal isolates, including E. faecalis, E. faecium...”
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  7. 37647
    Analysis of Repair Mechanisms following an Induced Double-Strand Break Uncovers Recessive Deleterious Alleles in the <named-content content-type="genus-species">Candida albicans</named-content> Diploid Genome
    “... in the genomes of strain SC5314 and two clinical isolates. Our results demonstrate that recessive lethal alleles...”
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  8. 37648
    The ADP-Ribosyltransferase Domain of the Effector Protein ExoS Inhibits Phagocytosis of <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> during Pneumonia
    “... to severe disease and worse clinical outcomes in animal and human studies. The majority of P. aeruginosa...”
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  9. 37649
    Coagulase and Efb of <named-content content-type="genus-species">Staphylococcus aureus</named-content> Have a Common Fibrinogen Binding Motif
    “... developed during the past years. However, these vaccines have all failed in clinical trials. The ability...”
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  10. 37650
    Characterization of a Multipeptide Lantibiotic Locus in <named-content content-type="genus-species">Streptococcus pneumoniae</named-content>
    “... of the locus. Lantibiotics represent a relatively untapped resource for the development of clinically useful...”
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  11. 37651
    Strain Prioritization and Genome Mining for Enediyne Natural Products
    “... in sufficient quantities for chemical, biological, and clinical investigations. This work demonstrated...”
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  12. 37652
    Characterization of a Pathogenic Full-Length cDNA Clone and Transmission Model for Porcine Epidemic Diarrhea Virus Strain PC22A
    “... and evaluating the efficacy of live attenuated vaccines and therapeutics in a clinical setting. IMPORTANCE...”
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  13. 37653
    Complete Microbiota Engraftment Is Not Essential for Recovery from Recurrent <named-content content-type="genus-species">Clostridium difficile</named-content> Infection following Fecal Microbiota Transplantation
    “... in a previously published randomized clinical trial to treat recurrent C. difficile infection (rCDI...”
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  14. 37654
    Identification of Host Factors Involved in Human Cytomegalovirus Replication, Assembly, and Egress Using a Two-Step Small Interfering RNA Screen
    “... congenital birth defects. The majority of antivirals in clinical use target components of the virus...”
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  15. 37655
    Adhesion of <named-content content-type="genus-species">Staphylococcus aureus</named-content> to Corneocytes from Atopic Dermatitis Patients Is Controlled by Natural Moisturizing Factor Levels
    “... in the clinically important context of atopic dermatitis (AD), also known as eczema. We identify a unique...”
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  16. 37656
    An Attenuated CRISPR-Cas System in <named-content content-type="genus-species">Enterococcus faecalis</named-content> Permits DNA Acquisition
    “... strains, the genomes of multidrug-resistant (MDR) E. faecalis clinical isolates are enriched for mobile...”
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  17. 37657
    Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate
    “... support the clinical development of ZIKV-LAV for GBM therapy. IMPORTANCE Glioblastoma (GBM), the deadliest...”
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  18. 37658
    YejM Modulates Activity of the YciM/FtsH Protease Complex To Prevent Lethal Accumulation of Lipopolysaccharide
    “... and hydrophobic molecules. As such, these bacteria are intrinsically resistant to several clinically relevant...”
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  19. 37659
    Role of Dietary Flavonoid Compounds in Driving Patterns of Microbial Community Assembly
    “... range of clinical and epidemiologic settings. IMPORTANCE Dietary flavonoids, which have been implicated...”
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  20. 37660
    Repurposing Cytarabine for Treating Primary Effusion Lymphoma by Targeting Kaposi’s Sarcoma-Associated Herpesvirus Latent and Lytic Replications
    “... in advanced clinical trials....”
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