Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK.

por Long-Sheng Chang, Janet L Oblinger, Abbi E Smith, Marc Ferrer, Steven P Angus, Eric Hawley, Alejandra M Petrilli, Roberta L Beauchamp, Lars Björn Riecken, Serkan Erdin, Ming Poi, Jie Huang, Waylan K Bessler, Xiaohu Zhang, Rajarshi Guha, Craig Thomas, Sarah S Burns, Thomas S K Gilbert, Li Jiang, Xiaohong Li, Qingbo Lu, Jin Yuan, Yongzheng He, Shelley A H Dixon, Andrea Masters, David R Jones, Charles W Yates, Stephen J Haggarty, Salvatore La Rosa, D Bradley Welling, Anat O Stemmer-Rachamimov, Scott R Plotkin, James F Gusella, Justin Guinney, Helen Morrison, Vijaya Ramesh, Cristina Fernandez-Valle, Gary L Johnson, Jaishri O Blakeley, D Wade Clapp, Synodos for NF2 Consortium
Publicado 2021

Intracellular Water Lifetime as a Tumor Biomarker to Monitor Doxorubicin Treatment via FFC-Relaxometry in a Breast Cancer Model

por Maria Rosaria Ruggiero, Simona Baroni, Valeria Bitonto, Roberto Ruiu, Smeralda Rapisarda, Silvio Aime, Simonetta Geninatti Crich
Publicado 2021

Real-world data from a molecular tumor board demonstrates improved outcomes with a precision N-of-One strategy

por Shumei Kato, Ki Hwan Kim, Hyo Jeong Lim, Amelie Boichard, Mina Nikanjam, Elizabeth Weihe, Dennis J. Kuo, Ramez N. Eskander, Aaron Goodman, Natalie Galanina, Paul T. Fanta, Richard B. Schwab, Rebecca Shatsky, Steven C. Plaxe, Andrew Sharabi, Edward Stites, Jacob J. Adashek, Ryosuke Okamura, Suzanna Lee, Scott M. Lippman, Jason K. Sicklick, Razelle Kurzrock
Publicado 2020

Induction of mitochondria-mediated apoptosis and suppression of tumor growth in zebrafish xenograft...

por Sekar Jinendiran, Weilin Teng, Hans-Uwe Dahms, Wangta Liu, Vinoth Kumar Ponnusamy, Charles Chien-Chih Chiu, B. S. Dileep Kumar, Natesan Sivakumar
Publicado 2020

Diagnostic value of IMP3 and p53 immunohistochemical staining in EUS-guided fine-needle aspiration for solid pancreatic tumors

por Rintaro Mikata, Shin Yasui, Takashi Kishimoto, Yusuke Kouchi, Ayako Shingyoji, Junichi Senoo, Koji Takahashi, Hiroki Nagashima, Yuko Kusakabe, Hiroshi Ohyama, Izumi Ohno, Harutoshi Sugiyama, Tetsuhiro Chiba, Jun Kato, Naoya Kato
Publicado 2021

Concordance analysis of microsatellite instability status between polymerase chain reaction based testing and next generation sequencing for solid tumors

por Keitaro Shimozaki, Hideyuki Hayashi, Shigeki Tanishima, Sara Horie, Akihiko Chida, Kai Tsugaru, Kazuhiro Togasaki, Kenta Kawasaki, Eriko Aimono, Kenro Hirata, Hiroshi Nishihara, Takanori Kanai, Yasuo Hamamoto
Publicado 2021

Carboplatin response in preclinical models for ovarian cancer: comparison of 2D monolayers, spheroids, ex vivo tumors and in vivo models

por Melica Nourmoussavi Brodeur, Kayla Simeone, Kim Leclerc-Deslauniers, Hubert Fleury, Euridice Carmona, Diane M. Provencher, Anne-Marie Mes-Masson
Publicado 2021

Circulating tumor cell copy-number heterogeneity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors

por Marianne Oulhen, Patrycja Pawlikowska, Tala Tayoun, Marianna Garonzi, Genny Buson, Claudio Forcato, Nicolò Manaresi, Agathe Aberlenc, Laura Mezquita, Yann Lecluse, Pernelle Lavaud, Charles Naltet, David Planchard, Benjamin Besse, Françoise Farace
Publicado 2021

Changes over time in inflammatory and structural lesions at the sacroiliac joint in children with spondyloarthritis exposed and unexposed to tumor necrosis factor inhibitor

por Timothy G. Brandon, Rui Xiao, Rosemary G. Peterson, Nancy A. Chauvin, Michael L. Francavilla, David M. Biko, Dax G. Rumsey, Matthew L. Stoll, Pamela F. Weiss
Publicado 2021

Hsa-miR-21-3p associates with breast cancer patient survival and targets genes in tumor suppressive pathways.

por Arsalan Amirfallah, Hildur Knutsdottir, Adalgeir Arason, Bylgja Hilmarsdottir, Oskar T Johannsson, Bjarni A Agnarsson, Rosa B Barkardottir, Inga Reynisdottir
Publicado 2021

Investigating difficult to detect pancreatic lesions: Characterization of benign pancreatic islet cell tumors using multiparametric pancreatic 3-T MRI.

por Kwadwo Antwi, Patricia Wiesner, Elmar M Merkle, Christoph J Zech, Daniel T Boll, Damian Wild, Emanuel Christ, Tobias Heye
Publicado 2021

miR-361-5p as a promising qRT-PCR internal control for tumor and normal breast tissues.

por Sogol Ghanbari, Adel Salimi, Saeid Rahmani, Nahid Nafissi, Ali Sharifi-Zarchi, Seyed Javad Mowla
Publicado 2021

Core genes involved in the regulation of acute lung injury and their association with COVID-19 and tumor progression: A bioinformatics and experimental study.

por Aleksandra V Sen'kova, Innokenty A Savin, Evgenyi V Brenner, Marina A Zenkova, Andrey V Markov
Publicado 2021

Mouse papillomavirus type 1 (MmuPV1) DNA is frequently integrated in benign tumors by microhomology-mediated end-joining.

por Lulu Yu, Vladimir Majerciak, Xiang-Yang Xue, Aayushi Uberoi, Alexei Lobanov, Xiongfong Chen, Maggie Cam, Stephen H Hughes, Paul F Lambert, Zhi-Ming Zheng
Publicado 2021

A rapid nanobiosensing platform based on herceptin-conjugated graphene for ultrasensitive detection of circulating tumor cells in early breast cancer

por Rahimzadeh Zahra, Naghib Seyed Morteza, Askari Esfandyar, Molaabasi Fatemeh, Sadr Ali, Zare Yasser, Afsharpad Mandana, Rhee Kyong Yop
Publicado 2021

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors

por O. C. Bedoya-Reina, W. Li, M. Arceo, M. Plescher, P. Bullova, H. Pui, M. Kaucka, P. Kharchenko, T. Martinsson, J. Holmberg, I. Adameyko, Q. Deng, C. Larsson, C. C. Juhlin, P. Kogner, S. Schlisio
Publicado 2021

Tumor perfusion evaluation using dynamic contrast-enhanced ultrasound after electrochemotherapy and IL-12 plasmid electrotransfer in murine melanoma

por Maja Brloznik, Nina Boc, Maja Cemazar, Gregor Sersa, Masa Bosnjak, Simona Kranjc Brezar, Darja Pavlin
Publicado 2021

Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery

por F. J. Voskuil, P. J. Steinkamp, T. Zhao, B. van der Vegt, M. Koller, J. J. Doff, Y. Jayalakshmi, J. P. Hartung, J. Gao, B. D. Sumer, M. J. H. Witjes, G. M. van Dam, the SHINE study group
Publicado 2020

Proteasome inhibition by bortezomib parallels a reduction in head and neck cancer cells growth, and an increase in tumor-infiltrating immune cells

por Monica Benvenuto, Sara Ciuffa, Chiara Focaccetti, Diego Sbardella, Sara Fazi, Manuel Scimeca, Grazia Raffaella Tundo, Giovanni Barillari, Maria Segni, Elena Bonanno, Vittorio Manzari, Andrea Modesti, Laura Masuelli, Massimo Coletta, Roberto Bei
Publicado 2021

Tumor microenvironment-adjusted prognostic implications of the KRAS mutation subtype in patients with stage III colorectal cancer treated with adjuvant FOLFOX

por Hye Eun Park, Seung-Yeon Yoo, Nam-Yun Cho, Jeong Mo Bae, Sae-Won Han, Hye Seung Lee, Kyu Joo Park, Tae-You Kim, Gyeong Hoon Kang
Publicado 2021