Assessing the cognitive status of Drosophila by the value-based feeding decision

by Chih-Chieh Yu, Ferng-Chang Chang, Yong-Huei Hong, Jian-Chiuan Li, Po-Lin Chen, Chun-Hong Chen, Tzai-Wen Chiu, Tsai-Te Lu, Yun-Ming Wang, Chih-Fei Kao
Published 2021

Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system

by Weng Kung Peng, Lan Chen, Bernhard O. Boehm, Jongyoon Han, Tze Ping Loh
Published 2020

Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart

by Yankun Lyu, Vipin K. Verma, Younjee Lee, Iosif Taleb, Rachit Badolia, Thirupura S. Shankar, Christos P. Kyriakopoulos, Craig H. Selzman, William Caine, Rami Alharethi, Sutip Navankasattusas, Thomas Seidel, Stavros G. Drakos, Frank B. Sachse
Published 2021

The aging human body shape

by Alexander Frenzel, Hans Binder, Nadja Walter, Kerstin Wirkner, Markus Loeffler, Henry Loeffler-Wirth
Published 2020

Repository of proposed pathways and protein–protein interaction networks in age-related macular degeneration

by Fran M. Pool, Christina Kiel, Luis Serrano, Philip J. Luthert
Published 2020

Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss

by Tetsuya Oishi, Daisuke Matsumaru, Nao Ota, Hiroshi Kitamura, Tianxiang Zhang, Yohei Honkura, Yukio Katori, Hozumi Motohashi
Published 2020

CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves

by Sean Johnson, David F. Wozniak, S. Imai
Published 2018

Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies

by Megumi Hatori, Claude Gronfier, Russell N. Van Gelder, Paul S. Bernstein, Josep Carreras, Satchidananda Panda, Frederick Marks, David Sliney, Charles E. Hunt, Tsuyoshi Hirota, Toshiharu Furukawa, Kazuo Tsubota
Published 2017

Physician-initiated clinical study of limb ulcers treated with a functional peptide, SR-0379: from discovery to a randomized, double-blind, placebo-controlled trial

by Hironori Nakagami, Ken Sugimoto, Takahiro Ishikawa, Taku Fujimoto, Toshifumi Yamaoka, Misa Hayashi, Eiji Kiyohara, Hiroshi Ando, Yuta Terabe, Yoichi Takami, Koichi Yamamoto, Yasushi Takeya, Minoru Takemoto, Masaya Koshizaka, Tamotsu Ebihara, Ayumi Nakamura, Mitsunori Nishikawa, Xiang Jing Yao, Hideki Hanaoka, Ichiro Katayama, Koutaro Yokote, Hiromi Rakugi
Published 2018

NQO1 protects obese mice through improvements in glucose and lipid metabolism

by Andrea Di Francesco, Youngshim Choi, Michel Bernier, Yingchun Zhang, Alberto Diaz-Ruiz, Miguel A. Aon, Krystle Kalafut, Margaux R. Ehrlich, Kelsey Murt, Ahmed Ali, Kevin J. Pearson, Sophie Levan, Joshua D. Preston, Alejandro Martin-Montalvo, Jennifer L. Martindale, Kotb Abdelmohsen, Cole R. Michel, Diana M. Willmes, Christine Henke, Placido Navas, Jose Manuel Villalba, David Siegel, Myriam Gorospe, Kristofer Fritz, Shyam Biswal, David Ross, Rafael de Cabo
Published 2020

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy

by Tugsan Tezil, Manish Chamoli, Che-Ping Ng, Roman P. Simon, Victoria J. Butler, Manfred Jung, Julie Andersen, Aimee W. Kao, Eric Verdin
Published 2019

New drugs for pharmacological extension of replicative life span in normal and progeroid cells

by Sergei Vatolin, Tomas Radivoyevitch, Jaroslaw P. Maciejewski
Published 2019

Periodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice

by Naoyuki Ishida, Yuichi Ishihara, Kazuto Ishida, Hiroyuki Tada, Yoshiko Funaki-Kato, Makoto Hagiwara, Taslima Ferdous, Mohammad Abdullah, Akio Mitani, Makoto Michikawa, Kenji Matsushita
Published 2017

Treatment of diabetic mice with the SGLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality

by Taichi Sugizaki, Shunshun Zhu, Ge Guo, Akiko Matsumoto, Jiabin Zhao, Motoyoshi Endo, Haruki Horiguchi, Jun Morinaga, Zhe Tian, Tsuyoshi Kadomatsu, Keishi Miyata, Hiroshi Itoh, Yuichi Oike
Published 2017

Clampdown of inflammation in aging and anticancer therapies by limiting upregulation and activation of GPCR, CXCR4

by Raji R. Nair, Shreyas V. Madiwale, Deepak Kumar Saini
Published 2018

Conserved and species-specific molecular denominators in mammalian skeletal muscle aging

by Evi M. Mercken, Miriam Capri, Bethany A. Carboneau, Maria Conte, Juliana Heidler, Aurelia Santoro, Alejandro Martin-Montalvo, Marta Gonzalez-Freire, Husam Khraiwesh, José A. González-Reyes, Ruin Moaddel, Yongqing Zhang, Kevin G. Becker, José M. Villalba, Julie A. Mattison, Ilka Wittig, Claudio Franceschi, Rafael de Cabo
Published 2017

Caveolin-1 as a pathophysiological factor and target in psoriasis

by Ilja L. Kruglikov, Philipp E. Scherer
Published 2019

Both overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of Drosophila melanogaster

by Jelle Zandveld, Joost van den Heuvel, Bastiaan J. Zwaan, Matthew D.W. Piper
Published 2017

How does hormesis impact biology, toxicology, and medicine?

by Edward J. Calabrese, Mark P. Mattson
Published 2017

Blocking negative effects of senescence in human skin fibroblasts with a plant extract

by Ingo Lämmermann, Lucia Terlecki-Zaniewicz, Regina Weinmüllner, Markus Schosserer, Hanna Dellago, André Dargen de Matos Branco, Dominik Autheried, Benjamin Sevcnikar, Lisa Kleissl, Irina Berlin, Frédérique Morizot, Francois Lejeune, Nicola Fuzzati, Sandra Forestier, Alix Toribio, Anaïs Tromeur, Lionel Weinberg, Juan Carlos Higareda Almaraz, Marcel Scheideler, Marion Rietveld, Abdoel El Ghalbzouri, Erwin Tschachler, Florian Gruber, Johannes Grillari
Published 2018