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  1. 4361
    Timeliness of antiretroviral therapy initiation in the era before universal treatment
    “.... Early ART initiation led to durable viral load suppression and was not associated with a subsequent gap...”
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  2. 4362
    Knockdown of SPRY4 and SPRY4-IT1 inhibits cell growth and phosphorylation of Akt in human testicular germ cell tumours
    “..., and invasion. Knockdown of SPRY4 and SPRY4-IT1 also led to a significant reduction in the phosphorylation...”
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  3. 4363
    Two Tau binding sites on tubulin revealed by thiol-disulfide exchanges
    “... or Tau-induced MTs, associated to a comparison of structural data, led us to propose two putative binding...”
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  4. 4364
    A missense mutation in TRAPPC6A leads to build-up of the protein, in patients with a neurodevelopmental syndrome and dysmorphic features
    “... comparative genomic hybridisation (CGH) to identify regions of homozygosity, with exome sequencing, led...”
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  5. 4365
    Structural insights into the RNA methyltransferase domain of METTL16
    “... led to a model of the methyl transfer reaction catalyzed by METTL16. In contrast to the major m6A...”
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  6. 4366
    Cytochrome C oxidase Inhibition and Cold Plasma-derived Oxidants Synergize in Melanoma Cell Death Induction
    “... that led to rapid onset of caspase-independent melanoma cell death. This was mediated by mitochondrial...”
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  7. 4367
    Effect of in-situ aged and fresh biochar on soil hydraulic conditions and microbial C use under drought conditions
    “... mineralization increased most for soils containing BCaged. The BCaged led to improved C use under drought...”
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  8. 4368
    A model to rate strategies for managing disease due to COVID-19 infection
    por Shiyan Wang, Doraiswami Ramkrishna
    Publicado 2020
    “... arisen from public discussion led by medical professionals. Yet understanding of these factors has been...”
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  9. 4369
    Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons
    “... that the ablation of Ffar3 gene expression in two knockout mouse models led to a complete loss-of-function...”
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  10. 4370
    Ricinus communis L. fruit extract inhibits migration/invasion, induces apoptosis in breast cancer cells and arrests tumor progression in vivo
    “... treatment. RCFE (0.5 mg/Kg body weight) treatment led to significant reduction in tumor volume in 4T1...”
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  11. 4371
    Right versus left ventricular remodeling in heart failure due to chronic volume overload
    “... expression and proteomics were studied. ACF led to biventricular dilatation, systolic dysfunction...”
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  12. 4372
    Nivolumab in combination with cabozantinib for metastatic triple-negative breast cancer: a phase II and biomarker study
    “... achieved a partial response (ORR 6%), and the trial was stopped early. Toxicity led to cabozantinib dose...”
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  13. 4373
    TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells
    “... deficiency also led to a Pim2-dependent increase in c-Myc protein levels and was associated with reduced c...”
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  14. 4374
    Retinoic acid receptor α as a novel contributor to adrenal cortex structure and function through interactions with Wnt and Vegfa signalling
    “... the adrenal phenotype of male and female Rarα knockout mice. Inactivation of Rarα in mice led to significant...”
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  15. 4375
    Endangered Atlantic Sturgeon in the New York Wind Energy Area: implications of future development in an offshore wind energy site
    “... States has led to significant concerns for marine wildlife. The scarcity of empirical data regarding fish...”
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  16. 4376
    An algorithm-based meta-analysis of genome- and proteome-wide data identifies a combination of potential plasma biomarkers for colorectal cancer
    “... research has led to the identification of a large number of different types of biomarkers, few of which...”
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  17. 4377
    Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch
    “...), as well as lines expressing GST only as a control. Interestingly, overexpression of GST-KLF1 DBD led...”
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  18. 4378
    CRISPR/Cas9 editing reveals novel mechanisms of clustered microRNA regulation and function
    “... expression. In the case of the miR-497~195 cluster, editing of miR-195 led to a significant decrease...”
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  19. 4379
    Re-exploration of U’s Triangle Brassica Species Based on Chloroplast Genomes and 45S nrDNA Sequences
    “... on chloroplast genome and ribosomal DNA variations. Our phylogenomic analyses led to two main conclusions. (1...”
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  20. 4380
    A PPARγ-dependent miR-424/503-CD40 axis regulates inflammation mediated angiogenesis
    “..., which directly target its 3′ untranslated region. Pro-inflammatory stimuli led to increased endothelial...”
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