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  1. 7101
    Deletion of <italic toggle="yes">nuoG</italic> from the Vaccine Candidate <named-content content-type="genus-species">Mycobacterium bovis</named-content> BCG Δ<italic toggle="yes">ureC</italic>::<italic toggle="yes">hly</italic> Improves Protection against Tuberculosis
    “... dehydrogenase 1 subunit G, from BCG ΔureC::hly. In vitro, deletion of nuoG unexpectedly led to strongly...”
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  2. 7102
    <italic toggle="yes">Candida albicans</italic> Chitin Increases Arginase-1 Activity in Human Macrophages, with an Impact on Macrophage Antimicrobial Functions
    “... production by induction of the substrate-competing host enzyme arginase-1. This led to a reduced production...”
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  3. 7103
    Identification of a Gamma Interferon-Activated Inhibitor of Translation-Like RNA Motif at the 3′ End of the Transmissible Gastroenteritis Coronavirus Genome Modulating Innate Immune Response
    “... of the viral GAIT-like RNA motif led to an exacerbated innate immune response triggered by MDA5, indicating...”
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  4. 7104
    Twin-Arginine Translocation System in <named-content content-type="genus-species">Helicobacter pylori</named-content>: TatC, but Not TatB, Is Essential for Viability
    por Stéphane L. Benoit, Robert J. Maier
    Publicado 2014
    “... and queA were easily obtained, attempts at disrupting tatA proved unsuccessful, while deletion of tatC led...”
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  5. 7105
    <named-content content-type="genus-species">Acinetobacter baumannii</named-content> Strain M2 Produces Type IV Pili Which Play a Role in Natural Transformation and Twitching Motility but Not Surface-Associated Motility
    “.... baumannii genomes have been sequenced; these data have led to the identification of many genes predicted...”
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  6. 7106
    Origins and Evolution of the Global RNA Virome
    “... genomes, including numerous human, animal, and plant pathogens. Recent advances of metagenomics have led...”
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  7. 7107
    Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis
    “... infection led to the hypersprouting formation of LECs, whereas infection with a ΔvIRF3 mutant did not do so...”
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  8. 7108
    Pyruvate Homeostasis as a Determinant of Parasite Growth and Metabolic Plasticity in <named-content content-type="genus-species">Toxoplasma gondii</named-content>
    “... activity to convert it to pyruvate. Moreover, depletion of PYK1 in conjunction with PYK2 ablation led...”
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  9. 7109
    TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function
    “...-infected macrophages led to decreased expression of BCL2, BCLXL, MFN1, and MFN2 and increased expression...”
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  10. 7110
    Conditional Protein Splicing Switch in Hyperthermophiles through an Intein-Extein Partnership
    “... RadA inteins led to the discovery that a nonconserved region (NCR) of the intein, a flexible loop where...”
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  11. 7111
    Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in <named-content content-type="genus-species">Escherichia coli</named-content>
    “... combinations such as piperacillin-tazobactam (TZP). However, our previous work led to the discovery of 28...”
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  12. 7112
    Physiological Heterogeneity Triggers Sibling Conflict Mediated by the Type VI Secretion System in an Aggregative Multicellular Bacterium
    “... led to social conflict where more-fit individuals killed their less-fit siblings. For the first time...”
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  13. 7113
    The BvgAS Regulon of <italic toggle="yes">Bordetella pertussis</italic>
    “... of whooping cough, caused by Bordetella pertussis, have led to respiratory disease and infant mortalities...”
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  14. 7114
    The <italic toggle="yes">Toxoplasma</italic> Centrocone Houses Cell Cycle Regulatory Factors
    “... machinery and the minichromosome maintenance complex, and the loss of ECR1 led to increased stability of a...”
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  15. 7115
    Development of Anti-Virulence Approaches for Candidiasis via a Novel Series of Small-Molecule Inhibitors of <italic toggle="yes">Candida albicans</italic> Filamentation
    “... in order to identify small-molecule inhibitors of C. albicans filamentation, and our efforts led...”
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  16. 7116
    The NOX Family of Proteins Is Also Present in Bacteria
    “... families have led to new structures, further mechanistic studies, and the improvement of inhibitors...”
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  17. 7117
    Viral DNA Replication Orientation and hnRNPs Regulate Transcription of the Human Papillomavirus 18 Late Promoter
    “.... Confirming this result, knocking down the expression of both hnRNPs in keratinocytes led to increased...”
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  18. 7118
    Efficient Gene Disruption in Diverse Strains of <named-content content-type="genus-species">Toxoplasma gondii</named-content> Using CRISPR/CAS9
    “...), a system of DNA recognition used as a defense mechanism in bacteria and archaea, has led...”
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  19. 7119
    Inactivation of <italic toggle="yes">thyA</italic> in <named-content content-type="genus-species">Staphylococcus aureus</named-content> Attenuates Virulence and Has a Strong Impact on Metabolism and Virulence Gene Expression
    “... that mutations in thyA were leading to inactivity of TS proteins, and TS inactivity led to tremendous impact...”
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  20. 7120
    <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Lsr2 Is a Global Transcriptional Regulator Required for Adaptation to Changing Oxygen Levels and Virulence
    “.... The defect in anaerobic adaptation led to a marked decrease in viability during anaerobiosis, as well as a...”
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