Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs

por Lifeng Fu, Shuai Shao, Yong Feng, Fei Ye, Xue Sun, Qingling Wang, Feng Yu, Qisheng Wang, Baoying Huang, Peihua Niu, Xuebing Li, Catherine C. L. Wong, Jianxun Qi, Wenjie Tan, George Fu Gao
Publicado 2021

Enhanced Carbapenem Resistance through Multimerization of Plasmids Carrying Carbapenemase Genes

por Ryuichiro Abe, Yukihiro Akeda, Yo Sugawara, Yuki Matsumoto, Daisuke Motooka, Ryuji Kawahara, Norihisa Yamamoto, Kazunori Tomono, Tetsuya Iida, Shigeyuki Hamada
Publicado 2021

Novel Symbiotic Genome-Scale Model Reveals <i>Wolbachia</i> 's Arboviral Pathogen Blocking Mechanism in Aedes aegypti

por Natalia E. Jiménez, Ziomara P. Gerdtzen, Álvaro Olivera-Nappa, J. Cristian Salgado, Carlos Conca
Publicado 2021

An Engineered Receptor-Binding Domain Improves the Immunogenicity of Multivalent SARS-CoV-2 Vaccines

por Yan Guo, Wenhui He, Huihui Mou, Lizhou Zhang, Jing Chang, Shoujiao Peng, Amrita Ojha, Rubens Tavora, Mark S. Parcells, Guangxiang Luo, Wenhui Li, Guocai Zhong, Hyeryun Choe, Michael Farzan, Brian D. Quinlan
Publicado 2021

Foraging Signals Promote Swarming in Starving Pseudomonas aeruginosa

por Divakar Badal, Abhijith Vimal Jayarani, Mohammad Ameen Kollaran, Deep Prakash, Monisha P, Varsha Singh
Publicado 2021

The DnaK/DnaJ Chaperone System Enables RNA Polymerase-DksA Complex Formation in Salmonella Experiencing Oxidative Stress

por Ju-Sim Kim, Lin Liu, Andrés Vázquez-Torres
Publicado 2021

A TonB-Like Protein, SjdR, Is Involved in the Structural Definition of the Intercellular Septa in the Heterocyst-Forming Cyanobacterium <i>Anabaena</i>

por Hannah Schätzle, Sergio Arévalo, Enrique Flores, Enrico Schleiff
Publicado 2021

Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii

por Zhemin Zhang, Christopher E. Morgan, Robert A. Bonomo, Edward W. Yu
Publicado 2021

Functional Genomic and Biochemical Analysis Reveals Pleiotropic Effect of Congo Red on Aspergillus fumigatus

por Zhonghua Liu, Shriya Raj, Norman van Rhijn, Marcin Fraczek, Jean-Philippe Michel, Odile Sismeiro, Rachel Legendre, Hugo Varet, Thierry Fontaine, Michael Bromley, Jean-Paul Latgé
Publicado 2021

A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants

por Denise Haslwanter, M. Eugenia Dieterle, Anna Z. Wec, Cecilia M. O’Brien, Mrunal Sakharkar, Catalina Florez, Karen Tong, C. Garrett Rappazzo, Gorka Lasso, Olivia Vergnolle, Ariel S. Wirchnianski, Robert H. Bortz, Ethan Laudermilch, J. Maximilian Fels, Amanda Mengotto, Ryan J. Malonis, George I. Georgiev, Jose A. Quiroz, Daniel Wrapp, Nianshuang Wang, Kathryn E. Dye, Jason Barnhill, John M. Dye, Jason S. McLellan, Johanna P. Daily, Jonathan R. Lai, Andrew S. Herbert, Laura M. Walker, Kartik Chandran, Rohit K. Jangra
Publicado 2021

Two Distinct Bacterial Biofilm Components Trigger Metamorphosis in the Colonial Hydrozoan Hydractinia echinata

por Huijuan Guo, Maja Rischer, Martin Westermann, Christine Beemelmanns
Publicado 2021

Linking a Gene Cluster to Atranorin, a Major Cortical Substance of Lichens, through Genetic Dereplication and Heterologous Expression

por Wonyong Kim, Rundong Liu, Sunmin Woo, Kyo Bin Kang, Hyun Park, Young Hyun Yu, Hyung-Ho Ha, Seung-Yoon Oh, Ji Ho Yang, Hangun Kim, Sung-Hwan Yun, Jae-Seoun Hur
Publicado 2021

Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses

por Wilfried Posch, Marta Bermejo-Jambrina, Marion Steger, Christina Witting, Gabriel Diem, Paul Hörtnagl, Hubert Hackl, Cornelia Lass-Flörl, Lukas A. Huber, Teunis B. H. Geijtenbeek, Doris Wilflingseder
Publicado 2021

A Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases

por Zhizhen Li, Jianping Wu, Ji Zhou, Baoshi Yuan, Jiqiao Chen, Wanchen Wu, Lian Mo, Zhipeng Qu, Fei Zhou, Yingying Dong, Kai Huang, Zhiwei Liu, Tao Wang, Deebie Symmes, Jingliang Gu, Eiketsu Sho, Jingping Zhang, Ruihuan Chen, Ying Xu
Publicado 2021

A <i>Streptococcus</i> Quorum Sensing System Enables Suppression of Innate Immunity

por Kate M. Rahbari, Jennifer C. Chang, Michael J. Federle
Publicado 2021

The Membrane Composition Defines the Spatial Organization and Function of a Major Acinetobacter baumannii Drug Efflux System

por Maoge Zang, Hugo MacDermott-Opeskin, Felise G. Adams, Varsha Naidu, Jack K. Waters, Ashley B. Carey, Alex Ashenden, Kimberley T. McLean, Erin B. Brazel, Jhih-Hang Jiang, Alessandra Panizza, Claudia Trappetti, James C. Paton, Anton Y. Peleg, Ingo Köper, Ian T. Paulsen, Karl A. Hassan, Megan L. O’Mara, Bart A. Eijkelkamp
Publicado 2021

Synergism versus Additivity: Defining the Interactions between Common Disinfectants

por Daniel J. Noel, C. William Keevil, Sandra A. Wilks
Publicado 2021

Erratum for Crossette et al., “Metagenomic Quantification of Genes with Internal Standards”

por Emily Crossette, Jordan Gumm, Kathryn Langenfeld, Lutgarde Raskin, Melissa Duhaime, Krista Wigginton
Publicado 2021

The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral <i>UL4</i> / <i>UL5</i> Transcripts

por Ana Cristina Gonzalez-Perez, Markus Stempel, Emanuel Wyler, Christian Urban, Antonio Piras, Thomas Hennig, Sabina Ganskih, Yuanjie Wei, Albert Heim, Markus Landthaler, Andreas Pichlmair, Lars Dölken, Mathias Munschauer, Florian Erhard, Melanie M. Brinkmann
Publicado 2021

Isolation and Analysis of the Nisin Biosynthesis Complex NisBTC: further Insights into Their Cooperative Action

por Jingqi Chen, Oscar P. Kuipers
Publicado 2021