Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II

por Nandan Haloi, Po-Chao Wen, Qunli Cheng, Meiying Yang, Gayathri Natarajan, Amadou K. S. Camara, Wai-Meng Kwok, Emad Tajkhorshid
Publicado 2021

Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner

por Zhongqi Li, Xinyi Chen, Joaquim S. L. Vong, Lei Zhao, Junzhe Huang, Leo Y. C. Yan, Bonaventure Ip, Yun Kwok Wing, Hei-Ming Lai, Vincent C. T. Mok, Ho Ko
Publicado 2021

Structure and function analysis of a potent human neutralizing antibody CA521FALA against SARS-CoV-2

por Deyong Song, Wenbo Wang, Chuangchuang Dong, Zhenfei Ning, Xiu Liu, Chuan Liu, Guangying Du, Chunjie Sha, Kailin Wang, Jun Lu, Baiping Sun, Yanyan Zhao, Qiaoping Wang, Hongguang Xu, Ying Li, Zhenduo Shen, Jie Jiao, Ruiying Wang, Jingwei Tian, Wanhui Liu, Lan Wang, Yong-Qiang Deng, Changlin Dou
Publicado 2021

COMMD4 functions with the histone H2A-H2B dimer for the timely repair of DNA double-strand breaks

por Amila Suraweera, Neha S. Gandhi, Sam Beard, Joshua T. Burgess, Laura V. Croft, Emma Bolderson, Ali Naqi, Nicholas W. Ashton, Mark N. Adams, Kienan I. Savage, Shu-Dong Zhang, Kenneth J. O’Byrne, Derek J. Richard
Publicado 2021

Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex

por Arash Ahmadi, Katharina Till, Paul Hoff Backe, Pernille Blicher, Robin Diekmann, Mark Schüttpelz, Kyrre Glette, Jim Tørresen, Magnar Bjørås, Alexander D. Rowe, Bjørn Dalhus
Publicado 2021

Neutrophil-derived reactive oxygen species promote tumor colonization

por Jianghong Zhong, Qijing Li, Huqiao Luo, Rikard Holmdahl
Publicado 2021

An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement

por John C. O’Donnell, Erin M. Purvis, Kaila V. T. Helm, Dayo O. Adewole, Qunzhou Zhang, Anh D. Le, D. Kacy Cullen
Publicado 2021

Distribution of Stenasellidae in Africa and description of a new species of Metastenasellus from Cameroonian groundwaters

por Pountougnigni Oumarou Farikou, Piscart Christophe, Sob Nangou Paul Bertrand, Zebaze Togouet Serge Hubert
Publicado 2021

Critique on conclusions regarding toxic compounds in Jatropha curcas kernel cake

por George Francis, Harinder P. S. Makkar, Reinhold Carle, Martin Mittelbach, Michael Wink, Jorge Martinez Herrera, Rakshit Kodekalra, Klaus Becker
Publicado 2021

Infrared nanoscopy and tomography of intracellular structures

por Katerina Kanevche, David J. Burr, Dennis J. Nürnberg, Pascal K. Hass, Andreas Elsaesser, Joachim Heberle
Publicado 2021

KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth

por Michiko Shimoda, Yuanzhi Lyu, Kang-Hsin Wang, Ashish Kumar, Hiroki Miura, Joshua F. Meckler, Ryan R. Davis, Chanikarn Chantarasrivong, Chie Izumiya, Clifford G. Tepper, Ken-ichi Nakajima, Joseph Tuscano, Gustavo Barisone, Yoshihiro Izumiya
Publicado 2021

GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors

por Anne Helness, Jennifer Fraszczak, Charles Joly-Beauparlant, Halil Bagci, Christian Trahan, Kaifee Arman, Peiman Shooshtarizadeh, Riyan Chen, Marina Ayoub, Jean-François Côté, Marlene Oeffinger, Arnaud Droit, Tarik Möröy
Publicado 2021

Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2

por Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B. Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde
Publicado 2021

Critical role of backbone coordination in the mRNA recognition by RNA induced silencing complex

por Lizhe Zhu, Hanlun Jiang, Siqin Cao, Ilona Christy Unarta, Xin Gao, Xuhui Huang
Publicado 2021

Reply to: “Critique on conclusions regarding toxic compounds in Jatropha curcas kernel cake”

por Changhe Zhang, Xing-Hong Wang
Publicado 2021

Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection

por Joern Pezoldt, Carolin Wiechers, Florian Erhard, Ulfert Rand, Tanja Bulat, Michael Beckstette, Andrea Brendolan, Jochen Huehn, Ulrich Kalinke, Mathias Mueller, Birgit Strobl, Bart Deplancke, Luka Čičin-Šain, Katarzyna M. Sitnik
Publicado 2021

Mutant alleles differentially shape fitness and other complex traits in cattle

por Ruidong Xiang, Ed J. Breen, Sunduimijid Bolormaa, Christy J. Vander Jagt, Amanda J. Chamberlain, Iona M. Macleod, Michael E. Goddard
Publicado 2021

Crystal structure of human METTL6, the m3C methyltransferase

por Ran Chen, Jie Zhou, Ling Liu, Xue-Ling Mao, Xiaolong Zhou, Wei Xie
Publicado 2021

Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2

por Kanako Shimizu, Tomonori Iyoda, An Sanpei, Hiroshi Nakazato, Masahiro Okada, Shogo Ueda, Miyuki Kato-Murayama, Kazutaka Murayama, Mikako Shirouzu, Naoko Harada, Michihiro Hidaka, Shin-ichiro Fujii
Publicado 2021

ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function

por Adrián Cortés Sanchón, Harshitha Santhosh Kumar, Matilde Mantovani, Ivan Osinnii, José María Mateos, Andres Kaech, Dimitri Shcherbakov, Rashid Akbergenov, Erik C. Böttger
Publicado 2021