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  1. 1241
    Drug resistance in diploid yeast is acquired through dominant alleles, haploinsufficiency, gene duplication and aneuploidy.
    “..., missense alleles in all three subunits of yeast AMP-activated protein kinase confer resistance to 2...”
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  2. 1242
    Functional and structural analyses of novel Smith-Kingsmore Syndrome-Associated MTOR variants reveal potential new mechanisms and predictors of pathogenicity.
    “... missense mutations in MTOR. The pathogenicity of novel variants in MTOR in patients with neurodevelopmental...”
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  3. 1243
    Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration
    “... missense CASP6 single nucleotide polymorphism (SNP), causing the substitution of asparagine with threonine...”
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  4. 1244
    Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians
    “... concentration is associated with the SOD3 p.R231G missense variant genotype. To clarify the association among...”
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  5. 1245
    Epilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency – molecular profiling and functional rescue
    “... data we shortlisted 10 diverse missense mutations for characterisation. We used high-throughput calcium...”
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  6. 1246
    Profile of buparlisib and its potential in the treatment of breast cancer: evidence to date
    “... inhibiting the production of the secondary messenger phosphatidylinositol (3,4,5)-trisphosphate...”
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  7. 1247
    Expression and function of the cdgD gene, encoding a CHASE–PAS-DGC-EAL domain protein, in Azospirillum brasilense
    “... encoding proteins involved in the biosynthesis and degradation of the second messenger cyclic-di-GMP, which...”
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  8. 1248
    Development and characterization of Nb3Sn/Al2O3 superconducting multilayers for particle accelerators
    “... which destroy the low-dissipative Meissner state. Achieving higher accelerating gradients requires...”
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  9. 1249
    Molecular Structures and Biochemical Physiology of the Proteins Involved in Chemical Communications in Some Insect Species
    “... of their three-dimensional structures. Pheromones are naturally occuring odorless chemical messenger compounds...”
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  10. 1250
    Spatiotemporal properties of the action potential propagation in the mouse visual cortical slice analyzed by calcium imaging.
    “...The calcium ion (Ca(2+)) is an important messenger for signal transduction, and the intracellular...”
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  11. 1251
    Tristetraprolin Prevents Gastric Metaplasia in Mice by Suppressing Pathogenic InflammationSummary
    “... and oncogenic messenger RNAs. Here, we assess the role of TTP in regulating gastric inflammation and spasmolytic...”
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  12. 1252
    Simultaneous Two-Photon Voltage or Calcium Imaging and Multi-Channel Local Field Potential Recordings in Barrel Cortex of Awake and Anesthetized Mice
    “... existing database of this important second messenger. Interestingly, in the calcium imaging data, we found...”
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  13. 1253
    Myocarditis and Pericarditis following COVID-19 Vaccination: Inequalities in Age and Vaccine Types
    “... of messenger RNA (mRNA) vaccines. Overall, two mRNA vaccines were significantly associated with increased risks...”
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  14. 1254
    <i>KCNG1</i>-Related Syndromic Form of Congenital Neuromuscular Channelopathy in a Crossbred Calf
    “... sequencing revealed a heterozygous missense variant in <i>KCNG1</i> affecting an evolutionary conserved...”
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  15. 1255
    Chronic Pancreatitis: The True Pathogenic Culprit within the <i>SPINK1</i> N34S-Containing Haplotype Is No Longer at Large
    “... hypotheses tested addressed whether the N34S missense variant has a direct impact on enzyme structure...”
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  16. 1256
    Development of SNP Markers for White Immature Fruit Skin Color in Cucumber (<i>Cucumis sativus</i> L.) Using QTL-seq and Marker Analyses
    “... 3. SNP marker analysis uncovered the novel missense mutations in <i>Chr3CG52930</i> and <i>Chr3CG...”
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  17. 1257
    Hydrophobic Optimization of Functional Poly(TPAE-co-suberoyl chloride) for Extrahepatic mRNA Delivery following Intravenous Administration
    “...Messenger RNA (mRNA) has generated great attention due to its broad potential therapeutic...”
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  18. 1258
    Genetically engineered mice for combinatorial cardiovascular optobiology
    “... messengers InsP3 (optoα1AR) and cAMP (optoß2AR), or Ca2+-permeant membrane channels (CatCh2) in smooth muscle...”
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  19. 1259
    Release of Nonstop Ribosomes Is Essential
    “... stop codon. Almost all bacteria use the transfer-messenger RNA (tmRNA)-based trans-translation pathway...”
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  20. 1260
    Functional analysis of the Phycomyces carRA gene encoding the enzymes phytoene synthase and lycopene cyclase.
    “... and the correct processing of the carRA messenger was verified by RT-PCR. These results showed that Phycomyces...”
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