Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

por Maria L. Agostini, Erica L. Andres, Amy C. Sims, Rachel L. Graham, Timothy P. Sheahan, Xiaotao Lu, Everett Clinton Smith, James Brett Case, Joy Y. Feng, Robert Jordan, Adrian S. Ray, Tomas Cihlar, Dustin Siegel, Richard L. Mackman, Michael O. Clarke, Ralph S. Baric, Mark R. Denison
Publicado 2018

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

por Timothy P. Sheahan, Amy C. Sims, Sarah R. Leist, Alexandra Schäfer, John Won, Ariane J. Brown, Stephanie A. Montgomery, Alison Hogg, Darius Babusis, Michael O. Clarke, Jamie E. Spahn, Laura Bauer, Scott Sellers, Danielle Porter, Joy Y. Feng, Tomas Cihlar, Robert Jordan, Mark R. Denison, Ralph S. Baric
Publicado 2020

The biosecurity benefits of genetic engineering attribution

por Gregory Lewis, Jacob L. Jordan, David A. Relman, Gregory D. Koblentz, Jade Leung, Allan Dafoe, Cassidy Nelson, Gerald L. Epstein, Rebecca Katz, Michael Montague, Ethan C. Alley, Claire Marie Filone, Stephen Luby, George M. Church, Piers Millett, Kevin M. Esvelt, Elizabeth E. Cameron, Thomas V. Inglesby
Publicado 2020

Short-channel field-effect transistors with 9-atom and 13-atom wide graphene nanoribbons

por Juan Pablo Llinas, Andrew Fairbrother, Gabriela Borin Barin, Wu Shi, Kyunghoon Lee, Shuang Wu, Byung Yong Choi, Rohit Braganza, Jordan Lear, Nicholas Kau, Wonwoo Choi, Chen Chen, Zahra Pedramrazi, Tim Dumslaff, Akimitsu Narita, Xinliang Feng, Klaus Müllen, Felix Fischer, Alex Zettl, Pascal Ruffieux, Eli Yablonovitch, Michael Crommie, Roman Fasel, Jeffrey Bokor
Publicado 2017

Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing

por Szi Kay Leung, Aaron R. Jeffries, Isabel Castanho, Ben T. Jordan, Karen Moore, Jonathan P. Davies, Emma L. Dempster, Nicholas J. Bray, Paul O’Neill, Elizabeth Tseng, Zeshan Ahmed, David A. Collier, Erin D. Jeffery, Shyam Prabhakar, Leonard Schalkwyk, Connor Jops, Michael J. Gandal, Gloria M. Sheynkman, Eilis Hannon, Jonathan Mill
Publicado 2021

A Single Salt Bridge in VIM-20 Increases Protein Stability and Antibiotic Resistance under Low-Zinc Conditions

por Zishuo Cheng, Ben A. Shurina, Christopher R. Bethel, Pei W. Thomas, Steven H. Marshall, Caitlyn A. Thomas, Kundi Yang, Robert L. Kimble, Jonathan S. Montgomery, Matthew G. Orischak, Callie M. Miller, Jordan L. Tennenbaum, Jay C. Nix, David L. Tierney, Walter Fast, Robert A. Bonomo, Richard C. Page, Michael W. Crowder
Publicado 2019

Genomic epidemiology reveals transmission patterns and dynamics of SARS-CoV-2 in Aotearoa New Zealand

por Jemma L. Geoghegan, Xiaoyun Ren, Matthew Storey, James Hadfield, Lauren Jelley, Sarah Jefferies, Jill Sherwood, Shevaun Paine, Sue Huang, Jordan Douglas, Fábio K. Mendes, Andrew Sporle, Michael G. Baker, David R. Murdoch, Nigel French, Colin R. Simpson, David Welch, Alexei J. Drummond, Edward C. Holmes, Sebastián Duchêne, Joep de Ligt
Publicado 2020

Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

por Lucy C. Walters, Karl Harlos, Simon Brackenridge, Daniel Rozbesky, Jordan R. Barrett, Vitul Jain, Thomas S. Walter, Chris A. O’Callaghan, Persephone Borrow, Mireille Toebes, Scott G. Hansen, Jonah B. Sacha, Shaheed Abdulhaqq, Justin M. Greene, Klaus Früh, Emily Marshall, Louis J. Picker, E. Yvonne Jones, Andrew J. McMichael, Geraldine M. Gillespie
Publicado 2018

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

por Lucy C. Walters, Karl Harlos, Simon Brackenridge, Daniel Rozbesky, Jordan R. Barrett, Vitul Jain, Thomas S. Walter, Chris A. O’Callaghan, Persephone Borrow, Mireille Toebes, Scott G. Hansen, Jonah B Sacha, Shaheed Abdulhaqq, Justin M. Greene, Klaus Früh, Emily Marshall, Louis J. Picker, E. Yvonne Jones, Andrew J. McMichael, Geraldine M. Gillespie
Publicado 2018

Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding

por Daniel W. Kulp, Jon M. Steichen, Matthias Pauthner, Xiaozhen Hu, Torben Schiffner, Alessia Liguori, Christopher A. Cottrell, Colin Havenar-Daughton, Gabriel Ozorowski, Erik Georgeson, Oleksandr Kalyuzhniy, Jordan R. Willis, Michael Kubitz, Yumiko Adachi, Samantha M. Reiss, Mia Shin, Natalia de Val, Andrew B. Ward, Shane Crotty, Dennis R. Burton, William R. Schief
Publicado 2017

A novel method of screening combinations of angiostatics identifies bevacizumab and temsirolimus as synergistic inhibitors of glioma-induced angiogenesis.

por Michael I Dorrell, Heidi R Kast-Woelbern, Ryan T Botts, Stephen A Bravo, Jacob R Tremblay, Sarah Giles, Jessica F Wada, MaryAnn Alexander, Eric Garcia, Gabriel Villegas, Caylor B Booth, Kaitlyn J Purington, Haylie M Everett, Erik N Siles, Michael Wheelock, Jordan A Silva, Bridget M Fortin, Connor A Lowey, Allison L Hale, Troy L Kurz, Jack C Rusing, Dawn M Goral, Paul Thompson, Alec M Johnson, Daniel J Elson, Roujih Tadros, Charisa E Gillette, Carley Coopwood, Amy L Rausch, Jeffrey M Snowbarger
Publicado 2021

Quantification of Early Neonatal Oxygen Exposure as a Risk Factor for Retinopathy of Prematurity Requiring Treatment

por Jimmy S. Chen, MD, Jamie E. Anderson, BS, Aaron S. Coyner, PhD, Susan Ostmo, MS, Kemal Sonmez, PhD, Deniz Erdogmus, PhD, Brian K. Jordan, MD, PhD, Cynthia T. McEvoy, MD, MCR, Dmitry Dukhovny, MD, MPH, Robert L. Schelonka, MD, R.V. Paul Chan, MD, Praveer Singh, PhD, Jayashree Kalpathy-Cramer, PhD, Michael F. Chiang, MD, MA, J. Peter Campbell, MD, MPH
Publicado 2021

High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19

por Winston A. Haynes, Kathy Kamath, Joel Bozekowski, Elisabeth Baum-Jones, Melissa Campbell, Arnau Casanovas-Massana, Patrick S. Daugherty, Charles S. Dela Cruz, Abhilash Dhal, Shelli F. Farhadian, Lynn Fitzgibbons, John Fournier, Michael Jhatro, Gregory Jordan, Jon Klein, Carolina Lucas, Debra Kessler, Larry L. Luchsinger, Brian Martinez, M. Catherine Muenker, Lauren Pischel, Jack Reifert, Jaymie R. Sawyer, Rebecca Waitz, Elsio A. Wunder, Minlu Zhang, Yale IMPACT Team, Akiko Iwasaki, Albert Ko, John C. Shon
Publicado 2021

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases.

por Craig B Wilen, Jianbin Wang, John C Tilton, Jeffrey C Miller, Kenneth A Kim, Edward J Rebar, Scott A Sherrill-Mix, Sean C Patro, Anthony J Secreto, Andrea P O Jordan, Gary Lee, Joshua Kahn, Pyone P Aye, Bruce A Bunnell, Andrew A Lackner, James A Hoxie, Gwenn A Danet-Desnoyers, Frederic D Bushman, James L Riley, Philip D Gregory, Carl H June, Michael C Holmes, Robert W Doms
Publicado 2011

Author Correction: Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment

por Min Zhang, Jin-Li Luo, Qianqian Sun, James Harber, Alan G. Dawson, Apostolos Nakas, Sara Busacca, Annabel J. Sharkey, David Waller, Michael T. Sheaff, Cathy Richards, Peter Wells-Jordan, Aarti Gaba, Charlotte Poile, Essa Y. Baitei, Aleksandra Bzura, Joanna Dzialo, Maymun Jama, John Le Quesne, Amrita Bajaj, Luke Martinson, Jacqui A. Shaw, Catrin Pritchard, Tamihiro Kamata, Nathaniel Kuse, Lee Brannan, Pan De Philip Zhang, Hongji Yang, Gareth Griffiths, Gareth Wilson, Charles Swanton, Frank Dudbridge, Edward J. Hollox, Dean A. Fennell
Publicado 2021

Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment

por Min Zhang, Jin-Li Luo, Qianqian Sun, James Harber, Alan G. Dawson, Apostolos Nakas, Sara Busacca, Annabel J. Sharkey, David Waller, Michael T. Sheaff, Cathy Richards, Peter Wells-Jordan, Aarti Gaba, Charlotte Poile, Essa Y. Baitei, Aleksandra Bzura, Joanna Dzialo, Maymun Jama, John Le Quesne, Amrita Bajaj, Luke Martison, Jacqui A. Shaw, Catrin Pritchard, Tamihiro Kamata, Nathaniel Kuse, Lee Brannan, Pan De Philip Zhang, Hongji Yang, Gareth Griffiths, Gareth Wilson, Charles Swanton, Frank Dudbridge, Edward J. Hollox, Dean A. Fennell
Publicado 2021

A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

por Jiandong Huo, Halina Mikolajek, Audrey Le Bas, Jordan J. Clark, Parul Sharma, Anja Kipar, Joshua Dormon, Chelsea Norman, Miriam Weckener, Daniel K. Clare, Peter J. Harrison, Julia A. Tree, Karen R. Buttigieg, Francisco J. Salguero, Robert Watson, Daniel Knott, Oliver Carnell, Didier Ngabo, Michael J. Elmore, Susan Fotheringham, Adam Harding, Lucile Moynié, Philip N. Ward, Maud Dumoux, Tessa Prince, Yper Hall, Julian A. Hiscox, Andrew Owen, William James, Miles W. Carroll, James P. Stewart, James H. Naismith, Raymond J. Owens
Publicado 2021

Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas

por Ana S. Guerreiro Stucklin, Scott Ryall, Kohei Fukuoka, Michal Zapotocky, Alvaro Lassaletta, Christopher Li, Taylor Bridge, Byungjin Kim, Anthony Arnoldo, Paul E. Kowalski, Yvonne Zhong, Monique Johnson, Claire Li, Arun K. Ramani, Robert Siddaway, Liana Figueiredo Nobre, Pasqualino de Antonellis, Christopher Dunham, Sylvia Cheng, Daniel R. Boué, Jonathan L. Finlay, Scott L. Coven, Inmaculada de Prada, Marta Perez-Somarriba, Claudia C. Faria, Michael A. Grotzer, Elisabeth Rushing, David Sumerauer, Josef Zamecnik, Lenka Krskova, Miguel Garcia Ariza, Ofelia Cruz, Andres Morales La Madrid, Palma Solano, Keita Terashima, Yoshiko Nakano, Koichi Ichimura, Motoo Nagane, Hiroaki Sakamoto, Maria Joao Gil-da-Costa, Roberto Silva, Donna L. Johnston, Jean Michaud, Bev Wilson, Frank K. H. van Landeghem, Angelica Oviedo, P. Daniel McNeely, Bruce Crooks, Iris Fried, Nataliya Zhukova, Jordan R. Hansford, Amulya Nageswararao, Livia Garzia, Mary Shago, Michael Brudno, Meredith S. Irwin, Ute Bartels, Vijay Ramaswamy, Eric Bouffet, Michael D. Taylor, Uri Tabori, Cynthia Hawkins
Publicado 2019

Genomic characterization of malignant progression in neoplastic pancreatic cysts

por Michaël Noë, Noushin Niknafs, Catherine G. Fischer, Wenzel M. Hackeng, Violeta Beleva Guthrie, Waki Hosoda, Marija Debeljak, Eniko Papp, Vilmos Adleff, James R. White, Claudio Luchini, Antonio Pea, Aldo Scarpa, Giovanni Butturini, Giuseppe Zamboni, Paola Castelli, Seung-Mo Hong, Shinichi Yachida, Nobuyoshi Hiraoka, Anthony J. Gill, Jaswinder S. Samra, G. Johan A. Offerhaus, Anne Hoorens, Joanne Verheij, Casper Jansen, N. Volkan Adsay, Wei Jiang, Jordan Winter, Jorge Albores-Saavedra, Benoit Terris, Elizabeth D. Thompson, Nicholas J. Roberts, Ralph H. Hruban, Rachel Karchin, Robert B. Scharpf, Lodewijk A. A. Brosens, Victor E. Velculescu, Laura D. Wood
Publicado 2020

Gene Expression in <italic toggle="yes">Leishmania</italic> Is Regulated Predominantly by Gene Dosage

por Stefano A. Iantorno, Caroline Durrant, Asis Khan, Mandy J. Sanders, Stephen M. Beverley, Wesley C. Warren, Matthew Berriman, David L. Sacks, James A. Cotton, Michael E. Grigg
Publicado 2017