Conformational changes in twitchin kinase in vivo revealed by FRET imaging of freely moving C. elegans

por Daniel Porto, Yohei Matsunaga, Barbara Franke, Rhys M Williams, Hiroshi Qadota, Olga Mayans, Guy M Benian, Hang Lu
Publicado 2021

Epithelial Aryl Hydrocarbon Receptor Protects From Mucus Production by Inhibiting ROS-Triggered NLRP3 Inflammasome in Asthma

por Xinyue Hu, Xinyue Hu, Yingchun Shen, Yilin Zhao, Ji Wang, Ji Wang, Ji Wang, Xin Zhang, Xin Zhang, Wei Tu, Wei Tu, William Kaufman, Juntao Feng, Peisong Gao
Publicado 2021

Complement-Mediated Differential Immune Response of Human Macrophages to Sporothrix Species Through Interaction With Their Cell Wall Peptidorhamnomannans

por Gabriela W. P. Neves, Sarah Sze Wah Wong, Vishukumar Aimanianda, Catherine Simenel, J. Iñaki Guijarro, Catriona Walls, Janet A. Willment, Janet A. Willment, Neil A. R. Gow, Neil A. R. Gow, Carol A. Munro, Gordon D. Brown, Gordon D. Brown, Leila M. Lopes-Bezerra, Leila M. Lopes-Bezerra
Publicado 2021

Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities

por Caitlin A. Nichols, William J. Gibson, Meredith S. Brown, Jack A. Kosmicki, John P. Busanovich, Hope Wei, Laura M. Urbanski, Naomi Curimjee, Ashton C. Berger, Galen F. Gao, Andrew D. Cherniack, Sirano Dhe-Paganon, Brenton R. Paolella, Rameen Beroukhim
Publicado 2020

Electromechanical coupling mechanism for activation and inactivation of an HCN channel

por Gucan Dai, Teresa K. Aman, Frank DiMaio, William N. Zagotta
Publicado 2021

Engineering new limits to magnetostriction through metastability in iron-gallium alloys

por P. B. Meisenheimer, R. A. Steinhardt, S. H. Sung, L. D. Williams, S. Zhuang, M. E. Nowakowski, S. Novakov, M. M. Torunbalci, B. Prasad, C. J. Zollner, Z. Wang, N. M. Dawley, J. Schubert, A. H. Hunter, S. Manipatruni, D. E. Nikonov, I. A. Young, L. Q. Chen, J. Bokor, S. A. Bhave, R. Ramesh, J.-M. Hu, E. Kioupakis, R. Hovden, D. G. Schlom, J. T. Heron
Publicado 2021

X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3

por Chiara Olcese, Mitali P. Patel, Amelia Shoemark, Santeri Kiviluoto, Marie Legendre, Hywel J. Williams, Cara K. Vaughan, Jane Hayward, Alice Goldenberg, Richard D. Emes, Mustafa M. Munye, Laura Dyer, Thomas Cahill, Jeremy Bevillard, Corinne Gehrig, Michel Guipponi, Sandra Chantot, Philippe Duquesnoy, Lucie Thomas, Ludovic Jeanson, Bruno Copin, Aline Tamalet, Christel Thauvin-Robinet, Jean- François Papon, Antoine Garin, Isabelle Pin, Gabriella Vera, Paul Aurora, Mahmoud R. Fassad, Lucy Jenkins, Christopher Boustred, Thomas Cullup, Mellisa Dixon, Alexandros Onoufriadis, Andrew Bush, Eddie M. K. Chung, Stylianos E. Antonarakis, Michael R. Loebinger, Robert Wilson, Miguel Armengot, Estelle Escudier, Claire Hogg, UK10K Rare Group, Serge Amselem, Zhaoxia Sun, Lucia Bartoloni, Jean-Louis Blouin, Hannah M. Mitchison
Publicado 2017

Two forms of death in ageing Caenorhabditis elegans

por Yuan Zhao, Ann F. Gilliat, Matthias Ziehm, Mark Turmaine, Hongyuan Wang, Marina Ezcurra, Chenhao Yang, George Phillips, David McBay, William B. Zhang, Linda Partridge, Zachary Pincus, David Gems
Publicado 2017

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

por Peter K. Joshi, Nicola Pirastu, Katherine A. Kentistou, Krista Fischer, Edith Hofer, Katharina E. Schraut, David W. Clark, Teresa Nutile, Catriona L. K. Barnes, Paul R. H. J. Timmers, Xia Shen, Ilaria Gandin, Aaron F. McDaid, Thomas Folkmann Hansen, Scott D. Gordon, Franco Giulianini, Thibaud S. Boutin, Abdel Abdellaoui, Wei Zhao, Carolina Medina-Gomez, Traci M. Bartz, Stella Trompet, Leslie A. Lange, Laura Raffield, Ashley van der Spek, Tessel E. Galesloot, Petroula Proitsi, Lisa R. Yanek, Lawrence F. Bielak, Antony Payton, Federico Murgia, Maria Pina Concas, Ginevra Biino, Salman M. Tajuddin, Ilkka Seppälä, Najaf Amin, Eric Boerwinkle, Anders D. Børglum, Archie Campbell, Ellen W. Demerath, Ilja Demuth, Jessica D. Faul, Ian Ford, Alessandro Gialluisi, Martin Gögele, MariaElisa Graff, Aroon Hingorani, Jouke-Jan Hottenga, David M. Hougaard, Mikko A. Hurme, M. Arfan Ikram, Marja Jylhä, Diana Kuh, Lannie Ligthart, Christina M. Lill, Ulman Lindenberger, Thomas Lumley, Reedik Mägi, Pedro Marques-Vidal, Sarah E. Medland, Lili Milani, Reka Nagy, William E. R. Ollier, Patricia A. Peyser, Peter P. Pramstaller, Paul M. Ridker, Fernando Rivadeneira, Daniela Ruggiero, Yasaman Saba, Reinhold Schmidt, Helena Schmidt, P. Eline Slagboom, Blair H. Smith, Jennifer A. Smith, Nona Sotoodehnia, Elisabeth Steinhagen-Thiessen, Frank J. A. van Rooij, André L. Verbeek, Sita H. Vermeulen, Peter Vollenweider, Yunpeng Wang, Thomas Werge, John B. Whitfield, Alan B. Zonderman, Terho Lehtimäki, Michele K. Evans, Mario Pirastu, Christian Fuchsberger, Lars Bertram, Neil Pendleton, Sharon L. R. Kardia, Marina Ciullo, Diane M. Becker, Andrew Wong, Bruce M. Psaty, Cornelia M. van Duijn, James G. Wilson, J. Wouter Jukema, Lambertus Kiemeney, André G. Uitterlinden, Nora Franceschini, Kari E. North, David R. Weir, Andres Metspalu, Dorret I. Boomsma, Caroline Hayward, Daniel Chasman, Nicholas G. Martin, Naveed Sattar, Harry Campbell, Tōnu Esko, Zoltán Kutalik, James F. Wilson
Publicado 2017

Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences

por D. Price, L. K. Tyler, R. Neto Henriques, K. L. Campbell, N. Williams, M.S. Treder, J. R. Taylor, Cam-CAN, R. N. A. Henson
Publicado 2017

Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve

por Bo Yang, Wei Zhou, Jiao Jiao, Jonas B. Nielsen, Michael R. Mathis, Mahyar Heydarpour, Guillaume Lettre, Lasse Folkersen, Siddharth Prakash, Claudia Schurmann, Lars Fritsche, Gregory A. Farnum, Maoxuan Lin, Mohammad Othman, Whitney Hornsby, Anisa Driscoll, Alexandra Levasseur, Marc Thomas, Linda Farhat, Marie-Pierre Dubé, Eric M. Isselbacher, Anders Franco-Cereceda, Dong-chuan Guo, Erwin P. Bottinger, G. Michael Deeb, Anna Booher, Sachin Kheterpal, Y. Eugene Chen, Hyun Min Kang, Jacob Kitzman, Heather J. Cordell, Bernard D. Keavney, Judith A. Goodship, Santhi K. Ganesh, Gonçalo Abecasis, Kim A. Eagle, Alan P. Boyle, Ruth J. F. Loos, Per Eriksson, Jean-Claude Tardif, Chad M. Brummett, Dianna M. Milewicz, Simon C. Body, Cristen J. Willer
Publicado 2017

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

por Sam Behjati, Patrick S. Tarpey, Kerstin Haase, Hongtao Ye, Matthew D. Young, Ludmil B. Alexandrov, Sarah J. Farndon, Grace Collord, David C. Wedge, Inigo Martincorena, Susanna L. Cooke, Helen Davies, William Mifsud, Mathias Lidgren, Sancha Martin, Calli Latimer, Mark Maddison, Adam P. Butler, Jon W. Teague, Nischalan Pillay, Adam Shlien, Ultan McDermott, P. Andrew Futreal, Daniel Baumhoer, Olga Zaikova, Bodil Bjerkehagen, Ola Myklebost, M. Fernanda Amary, Roberto Tirabosco, Peter Van Loo, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell
Publicado 2017

Killing by Type VI secretion drives genetic phase separation and correlates with increased cooperation

por Luke McNally, Eryn Bernardy, Jacob Thomas, Arben Kalziqi, Jennifer Pentz, Sam P. Brown, Brian K. Hammer, Peter J. Yunker, William C. Ratcliff
Publicado 2017

The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells

por Ian J. Huggins, Tomas Bos, Olivia Gaylord, Christina Jessen, Brianna Lonquich, Angeline Puranen, Jenna Richter, Charlotte Rossdam, David Brafman, Terry Gaasterland, Karl Willert
Publicado 2017

Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis

por Antonio Pierini, Hidekazu Nishikii, Jeanette Baker, Takaharu Kimura, Hye-Sook Kwon, Yuqiong Pan, Yan Chen, Maite Alvarez, William Strober, Andrea Velardi, Judith A. Shizuru, Joy Y. Wu, Shigeru Chiba, Robert S. Negrin
Publicado 2017

Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression

por Kévin Contrepois, Clément Coudereau, Bérénice A. Benayoun, Nadine Schuler, Pierre-François Roux, Oliver Bischof, Régis Courbeyrette, Cyril Carvalho, Jean-Yves Thuret, Zhihai Ma, Céline Derbois, Marie-Claire Nevers, Hervé Volland, Christophe E. Redon, William M. Bonner, Jean-François Deleuze, Clotilde Wiel, David Bernard, Michael P. Snyder, Claudia E. Rübe, Robert Olaso, François Fenaille, Carl Mann
Publicado 2017

Loss of Asxl2 leads to myeloid malignancies in mice

por Jianping Li, Fuhong He, Peng Zhang, Shi Chen, Hui Shi, Yanling Sun, Ying Guo, Hui Yang, Na Man, Sarah Greenblatt, Zhaomin Li, Zhengyu Guo, Yuan Zhou, Lan Wang, Lluis Morey, Sion Williams, Xi Chen, Qun-Tian Wang, Stephen D. Nimer, Peng Yu, Qian-Fei Wang, Mingjiang Xu, Feng-Chun Yang
Publicado 2017

Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC

por Sicai Zhang, Ronnie P.-A. Berntsson, William H. Tepp, Liang Tao, Eric A. Johnson, Pål Stenmark, Min Dong
Publicado 2017

Origin and evolution of the deep thermochemical structure beneath Eurasia

por N. Flament, S. Williams, R. D. Müller, M. Gurnis, D. J. Bower
Publicado 2017

Mismatch between marine plankton range movements and the velocity of climate change

por William J. Chivers, Anthony W. Walne, Graeme C. Hays
Publicado 2017