The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating.

por Chai Ann Ng, Matthew D Perry, Peter S Tan, Adam P Hill, Philip W Kuchel, Jamie I Vandenberg
Publicado 2012

The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation.

por Chai Ann Ng, Mark J Hunter, Matthew D Perry, Mehdi Mobli, Ying Ke, Philip W Kuchel, Glenn F King, Daniela Stock, Jamie I Vandenberg
Publicado 2011

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

por Charles D. Cox, Chilman Bae, Lynn Ziegler, Silas Hartley, Vesna Nikolova-Krstevski, Paul R. Rohde, Chai-Ann Ng, Frederick Sachs, Philip A. Gottlieb, Boris Martinac
Publicado 2016

Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations

por Jinyuan Vero Li, Chai-Ann Ng, Delfine Cheng, Zijing Zhou, Mingxi Yao, Yang Guo, Ze-Yan Yu, Yogambha Ramaswamy, Lining Arnold Ju, Philip W. Kuchel, Michael P. Feneley, Diane Fatkin, Charles D. Cox
Publicado 2021