The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating.

por Chai Ann Ng, Matthew D Perry, Peter S Tan, Adam P Hill, Philip W Kuchel, Jamie I Vandenberg
Publicado 2012

The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation.

por Chai Ann Ng, Mark J Hunter, Matthew D Perry, Mehdi Mobli, Ying Ke, Philip W Kuchel, Glenn F King, Daniela Stock, Jamie I Vandenberg
Publicado 2011