Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding

par Daniel W. Kulp, Jon M. Steichen, Matthias Pauthner, Xiaozhen Hu, Torben Schiffner, Alessia Liguori, Christopher A. Cottrell, Colin Havenar-Daughton, Gabriel Ozorowski, Erik Georgeson, Oleksandr Kalyuzhniy, Jordan R. Willis, Michael Kubitz, Yumiko Adachi, Samantha M. Reiss, Mia Shin, Natalia de Val, Andrew B. Ward, Shane Crotty, Dennis R. Burton, William R. Schief
Publié 2017

Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates.

par Jelle van Schooten, Marlies M van Haaren, Hui Li, Laura E McCoy, Colin Havenar-Daughton, Christopher A Cottrell, Judith A Burger, Patricia van der Woude, Leanne C Helgers, Ilhan Tomris, Celia C Labranche, David C Montefiori, Andrew B Ward, Dennis R Burton, John P Moore, Rogier W Sanders, Shane Crotty, George M Shaw, Marit J van Gils
Publié 2021

Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies

par Christopher A. Cottrell, Kartik Manne, Rui Kong, Shuishu Wang, Tongqing Zhou, Gwo-Yu Chuang, Robert J. Edwards, Rory Henderson, Katarzyna Janowska, Megan Kopp, Bob C. Lin, Mark K. Louder, Adam S. Olia, Reda Rawi, Chen-Hsiang Shen, Justin D. Taft, Jonathan L. Torres, Nelson R. Wu, Baoshan Zhang, Nicole A. Doria-Rose, Myron S. Cohen, Barton F. Haynes, Lawrence Shapiro, Andrew B. Ward, Priyamvada Acharya, John R. Mascola, Peter D. Kwong
Publié 2021

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

par Aleksandar Antanasijevic, Leigh M. Sewall, Christopher A. Cottrell, Diane G. Carnathan, Luis E. Jimenez, Julia T. Ngo, Jennifer B. Silverman, Bettina Groschel, Erik Georgeson, Jinal Bhiman, Raiza Bastidas, Celia LaBranche, Joel D. Allen, Jeffrey Copps, Hailee R. Perrett, Kimmo Rantalainen, Fabien Cannac, Yuhe R. Yang, Alba Torrents de la Peña, Rebeca Froes Rocha, Zachary T. Berndsen, David Baker, Neil P. King, Rogier W. Sanders, John P. Moore, Shane Crotty, Max Crispin, David C. Montefiori, Dennis R. Burton, William R. Schief, Guido Silvestri, Andrew B. Ward
Publié 2021

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

par Philip J. M. Brouwer, Aleksandar Antanasijevic, Zachary Berndsen, Anila Yasmeen, Brooke Fiala, Tom P. L. Bijl, Ilja Bontjer, Jacob B. Bale, William Sheffler, Joel D. Allen, Anna Schorcht, Judith A. Burger, Miguel Camacho, Daniel Ellis, Christopher A. Cottrell, Anna-Janina Behrens, Marco Catalano, Iván del Moral-Sánchez, Thomas J. Ketas, Celia LaBranche, Marit J. van Gils, Kwinten Sliepen, Lance J. Stewart, Max Crispin, David C. Montefiori, David Baker, John P. Moore, Per Johan Klasse, Andrew B. Ward, Neil P. King, Rogier W. Sanders
Publié 2019