Dynamic diagnosis of familial prion diseases supports the β2-α2 loop as a universal interference target.

por Massimiliano Meli, Maria Gasset, Giorgio Colombo
Publicado 2011

Modeling signal propagation mechanisms and ligand-based conformational dynamics of the Hsp90 molecular chaperone full-length dimer.

por Giulia Morra, Gennady Verkhivker, Giorgio Colombo
Publicado 2009

Revealing Escherichia coli type II l-asparaginase active site flexible loop in its open, ligand-free conformation

por Maristella Maggi, Massimiliano Meli, Giorgio Colombo, Claudia Scotti
Publicado 2021

Investigating the dynamic aspects of drug-protein recognition through a combination of MD and NMR analyses: implications for the development of protein-protein interaction inhibito...

por Massimiliano Meli, Katiuscia Pagano, Laura Ragona, Giorgio Colombo
Publicado 2014

Molecular mechanism of allosteric communication in Hsp70 revealed by molecular dynamics simulations.

por Federica Chiappori, Ivan Merelli, Giorgio Colombo, Luciano Milanesi, Giulia Morra
Publicado 2012

Methionine sulfoxides on prion protein Helix-3 switch on the alpha-fold destabilization required for conversion.

por Giorgio Colombo, Massimiliano Meli, Giulia Morra, Ruth Gabizon, María Gasset
Publicado 2009

A multiscale approach to characterize the early aggregation steps of the amyloid-forming peptide GNNQQNY from the yeast prion sup-35.

por Jessica Nasica-Labouze, Massimiliano Meli, Philippe Derreumaux, Giorgio Colombo, Normand Mousseau
Publicado 2011

The five-to-six-coordination transition of ferric human serum heme-albumin is allosterically-modulated by ibuprofen and warfarin: a combined XAS and MD study.

por Carlo Meneghini, Loris Leboffe, Monica Bionducci, Gabriella Fanali, Massimiliano Meli, Giorgio Colombo, Mauro Fasano, Paolo Ascenzi, Settimio Mobilio
Publicado 2014

Advancement in production engineering education through Virtual Learning Factory Toolkit concept

por Giorgio Colombo, Geza Heidegger, Peter Kovacs, Vladimir Kuts, Kashif Mahmood, Gianfranco E. Modoni, Tauno Otto, Johan Stahre, Walter Terkaj, Marcello Urgo
Publicado 2021

Direct and allosteric inhibition of the FGF2/HSPGs/FGFR1 ternary complex formation by an antiangiogenic, thrombospondin-1-mimic small molecule.

por Katiuscia Pagano, Rubben Torella, Chiara Foglieni, Antonella Bugatti, Simona Tomaselli, Lucia Zetta, Marco Presta, Marco Rusnati, Giulia Taraboletti, Giorgio Colombo, Laura Ragona
Publicado 2012

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell

por Miklos Bagdany, Guido Veit, Ryosuke Fukuda, Radu G. Avramescu, Tsukasa Okiyoneda, Imad Baaklini, Jay Singh, Guy Sovak, Haijin Xu, Pirjo M. Apaja, Sara Sattin, Lenore K. Beitel, Ariel Roldan, Giorgio Colombo, William Balch, Jason C. Young, Gergely L. Lukacs
Publicado 2017