Analysis of tumor mutational burden: correlation of five large gene panels with whole exome sequencing

por Carina Heydt, Jan Rehker, Roberto Pappesch, Theresa Buhl, Markus Ball, Udo Siebolts, Anja Haak, Philipp Lohneis, Reinhard Büttner, Axel M. Hillmer, Sabine Merkelbach-Bruse
Publicado 2020

Comparison of pre-analytical FFPE sample preparation methods and their impact on massively parallel sequencing in routine diagnostics.

por Carina Heydt, Jana Fassunke, Helen Künstlinger, Michaela Angelika Ihle, Katharina König, Lukas Carl Heukamp, Hans-Ulrich Schildhaus, Margarete Odenthal, Reinhard Büttner, Sabine Merkelbach-Bruse
Publicado 2014

ALK G1269A mutation as a potential mechanism of acquired resistance to crizotinib in an ALK-rearranged inflammatory myofibroblastic tumor

por Sebastian Y. F. Michels, Andreas H. Scheel, Thomas Wündisch, Johannes M. Heuckmann, Roopika Menon, Michael Puesken, Carsten Kobe, Helen Pasternack, Carina Heydt, Matthias Scheffler, Rieke Fischer, Anne M. Schultheis, Sabine Merkelbach-Bruse, Lukas Heukamp, Reinhard Büttner, Jürgen Wolf
Publicado 2017

Somatic alterations in circulating cell-free DNA of oesophageal carcinoma patients during primary staging are indicative for post-surgical tumour recurrence

por Helen Pasternack, Jana Fassunke, Patrick Sven Plum, Seung-Hun Chon, Daniel Alexander Hescheler, Asmae Gassa, Sabine Merkelbach-Bruse, Christiane Josephine Bruns, Sven Perner, Michael Hallek, Reinhard Büttner, Elfriede Bollschweiler, Arnulf Heinrich Hölscher, Alexander Quaas, Thomas Zander, Jonathan Weiss, Hakan Alakus
Publicado 2018

Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy

por Martin Thelen, Kerstin Wennhold, Jonas Lehmann, Maria Garcia-Marquez, Sebastian Klein, Elena Kochen, Philipp Lohneis, Axel Lechner, Svenja Wagener-Ryczek, Patrick Sven Plum, Oscar Velazquez Camacho, David Pfister, Fabian Dörr, Matthias Heldwein, Khosro Hekmat, Dirk Beutner, Jens Peter Klussmann, Fabinshy Thangarajah, Dominik Ratiu, Wolfram Malter, Sabine Merkelbach-Bruse, Christiane Josephine Bruns, Alexander Quaas, Michael von Bergwelt-Baildon, Hans A. Schlößer
Publicado 2021

Overcoming EGFR G724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors

por Jana Fassunke, Fabienne Müller, Marina Keul, Sebastian Michels, Marcel A. Dammert, Anna Schmitt, Dennis Plenker, Jonas Lategahn, Carina Heydt, Johannes Brägelmann, Hannah L. Tumbrink, Yannic Alber, Sebastian Klein, Alena Heimsoeth, Ilona Dahmen, Rieke N. Fischer, Matthias Scheffler, Michaela A. Ihle, Vanessa Priesner, Andreas H. Scheel, Svenja Wagener, Anna Kron, Konrad Frank, Katia Garbert, Thorsten Persigehl, Michael Püsken, Stefan Haneder, Bernhard Schaaf, Ernst Rodermann, Walburga Engel-Riedel, Enriqueta Felip, Egbert F. Smit, Sabine Merkelbach-Bruse, H. Christian Reinhardt, Stefan M. Kast, Jürgen Wolf, Daniel Rauh, Reinhard Büttner, Martin L. Sos
Publicado 2018