The conserved residue Arg46 in the N-terminal heptad repeat domain of HIV-1 gp41 is critical for viral fusion and entry.

by Xiaoyi Wang, Weiliang Xiong, Xiaochu Ma, Meili Wei, Yanxia Chen, Lu Lu, Asim K Debnath, Shibo Jiang, Chungen Pan
Published 2012

Identification of a human protein-derived HIV-1 fusion inhibitor targeting the gp41 fusion core structure.

by Lijun Chao, Lu Lu, Hengwen Yang, Yun Zhu, Yuan Li, Qian Wang, Xiaowen Yu, Shibo Jiang, Ying-Hua Chen
Published 2013

25-Hydroxycholesterol-Conjugated EK1 Peptide with Potent and Broad-Spectrum Inhibitory Activity against SARS-CoV-2, Its Variants of Concern, and Other Human Coronaviruses

by Qiaoshuai Lan, Chao Wang, Jie Zhou, Lijue Wang, Fanke Jiao, Yanbo Zhang, Yanxing Cai, Lu Lu, Shuai Xia, Shibo Jiang
Published 2021

Structure-based evidence for the enhanced transmissibility of the dominant SARS-CoV-2 B.1.1.7 variant (Alpha)

by Shuai Xia, Zuoling Wen, Lijue Wang, Qiaoshuai Lan, Fanke Jiao, Linhua Tai, Qian Wang, Fei Sun, Shibo Jiang, Lu Lu, Yun Zhu
Published 2021

Escape from humoral immunity is associated with treatment failure in HIV-1-infected patients receiving long-term antiretroviral therapy

by Yabo Ouyang, Qianqian Yin, Wei Li, Zhenpeng Li, Desheng Kong, Yanling Wu, Kunxue Hong, Hui Xing, Yiming Shao, Shibo Jiang, Tianlei Ying, Liying Ma
Published 2017

Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza

by Hanjun Zhao, Kelvin K. W. To, Hin Chu, Qiulu Ding, Xiaoyu Zhao, Cun Li, Huiping Shuai, Shuofeng Yuan, Jie Zhou, Kin-Hang Kok, Shibo Jiang, Kwok-Yung Yuen
Published 2018

Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines

by Lanying Du, Wanbo Tai, Yang Yang, Guangyu Zhao, Qing Zhu, Shihui Sun, Chang Liu, Xinrong Tao, Chien-Te K. Tseng, Stanley Perlman, Shibo Jiang, Yusen Zhou, Fang Li
Published 2016

Reply to ‘Trace N-glycans including sulphated species may originate from various plasma glycoproteins and not necessarily IgG’

by Jing-Rong Wang, Wei-Na Gao, Rudolf Grimm, Shibo Jiang, Yong Liang, Hua Ye, Zhan-Guo Li, Lee-Fong Yau, Hao Huang, Ju Liu, Min Jiang, Qiong Meng, Tian-Tian Tong, Hai-Hui Huang, Stephanie Lee, Xing Zeng, Liang Liu, Zhi-Hong Jiang
Published 2018

A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis

by Jing-Rong Wang, Wei-Na Gao, Rudolf Grimm, Shibo Jiang, Yong Liang, Hua Ye, Zhan-Guo Li, Lee-Fong Yau, Hao Huang, Ju Liu, Min Jiang, Qiong Meng, Tian-Tian Tong, Hai-Hui Huang, Stephanie Lee, Xing Zeng, Liang Liu, Zhi-Hong Jiang
Published 2017

A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses

by Yufeng Yu, Yong-Qiang Deng, Peng Zou, Qian Wang, Yanyan Dai, Fei Yu, Lanying Du, Na-Na Zhang, Min Tian, Jia-Nan Hao, Yu Meng, Yuan Li, Xiaohui Zhou, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Cheng-Feng Qin, Shibo Jiang, Lu Lu
Published 2017

Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2

by Hanjun Zhao, Kelvin K. W. To, Hoiyan Lam, Xinxin Zhou, Jasper Fuk-Woo Chan, Zheng Peng, Andrew C. Y. Lee, Jianpiao Cai, Wan-Mui Chan, Jonathan Daniel Ip, Chris Chung-Sing Chan, Man Lung Yeung, Anna Jinxia Zhang, Allen Wing Ho Chu, Shibo Jiang, Kwok-Yung Yuen
Published 2021

FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat

by Xinyi Yang, Xiaying Zhao, Yuqi Zhu, Yinzhong Shen, Yanan Wang, Panpan Lu, Zhengtao Jiang, Hanyu Pan, Jinlong Yang, Jingna Xun, Lin Zhao, Jing Wang, Zhiming Liang, Xiaoting Shen, Yue Liang, Qinru Lin, Huitong Liang, Lu Jin, Dengji Zhang, Jun Liu, Bin Wang, Shibo Jiang, Jianqing Xu, Hao Wu, Hongzhou Lu, Huanzhang Zhu
Published 2021

A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants

by Zhenlin Yang, Yulu Wang, Yujia Jin, Yuanfei Zhu, Yanling Wu, Cheng Li, Yu Kong, Wenping Song, Xiaolong Tian, Wuqiang Zhan, Ailing Huang, Shanshan Zhou, Shuai Xia, Xiaoxu Tian, Chao Peng, Cuicui Chen, Yibing Shi, Gaowei Hu, Shujuan Du, Yuyan Wang, Youhua Xie, Shibo Jiang, Lu Lu, Lei Sun, Yuanlin Song, Tianlei Ying
Published 2021

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

by Fei Li, Ming Han, Pengfei Dai, Wei Xu, Juan He, Xiaoting Tao, Yang Wu, Xinyuan Tong, Xinyi Xia, Wangxin Guo, Yunjiao Zhou, Yunguang Li, Yiqin Zhu, Xiaoyu Zhang, Zhuang Liu, Rebiguli Aji, Xia Cai, Yutang Li, Di Qu, Yu Chen, Shibo Jiang, Qiao Wang, Hongbin Ji, Youhua Xie, Yihua Sun, Lu Lu, Dong Gao
Published 2021