GenNet framework: interpretable deep learning for predicting phenotypes from genetic data

por Arno van Hilten, Steven A. Kushner, Manfred Kayser, M. Arfan Ikram, Hieab H. H. Adams, Caroline C. W. Klaver, Wiro J. Niessen, Gennady V. Roshchupkin
Publicado 2021

Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models

por Jadwiga Schreiber, Laura-Anne Grimbergen, Iris Overwater, Thijs van der Vaart, Jeffrey Stedehouder, Alberto J. Schuhmacher, Carmen Guerra, Steven A. Kushner, Dick Jaarsma, Ype Elgersma
Publicado 2017

An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum

por Gustavo A. Higuera, Grazia Iaffaldano, Meiwand Bedar, Guy Shpak, Robin Broersen, Shashini T. Munshi, Catherine Dupont, Joost Gribnau, Femke M. S. de Vrij, Steven A. Kushner, Chris I. De Zeeuw
Publicado 2017

Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice

por Saša Peter, Michiel M. ten Brinke, Jeffrey Stedehouder, Claudia M. Reinelt, Bin Wu, Haibo Zhou, Kuikui Zhou, Henk-Jan Boele, Steven A. Kushner, Min Goo Lee, Michael J. Schmeisser, Tobias M. Boeckers, Martijn Schonewille, Freek E. Hoebeek, Chris I. De Zeeuw
Publicado 2016

Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder

por Job O. de Jong, Ceyda Llapashtica, Matthieu Genestine, Kevin Strauss, Frank Provenzano, Yan Sun, Huixiang Zhu, Giuseppe P. Cortese, Francesco Brundu, Karlla W. Brigatti, Barbara Corneo, Bianca Migliori, Raju Tomer, Steven A. Kushner, Christoph Kellendonk, Jonathan A. Javitch, Bin Xu, Sander Markx
Publicado 2021

Engram-specific transcriptome profiling of contextual memory consolidation

por Priyanka Rao-Ruiz, Jonathan J. Couey, Ivo M. Marcelo, Christian G. Bouwkamp, Denise E. Slump, Mariana R. Matos, Rolinka J. van der Loo, Gabriela J. Martins, Mirjam van den Hout, Wilfred F. van IJcken, Rui M. Costa, Michel C. van den Oever, Steven A. Kushner
Publicado 2019

Phenotypic Differences between Asian and African Lineage Zika Viruses in Human Neural Progenitor Cells

por Fatih Anfasa, Jurre Y. Siegers, Mark van der Kroeg, Noreen Mumtaz, V. Stalin Raj, Femke M. S. de Vrij, W. Widagdo, Gülsah Gabriel, Sara Salinas, Yannick Simonin, Chantal Reusken, Steven A. Kushner, Marion P. G. Koopmans, Bart Haagmans, Byron E. E. Martina, Debby van Riel
Publicado 2017