Causal network models of SARS-CoV-2 expression and aging to identify candidates for drug repurposing
Given the severity of the SARS-CoV-2 pandemic, a major challenge is to rapidly repurpose existing approved drugs for clinical interventions. Here, the authors identify robust druggable protein targets within a principled causal framework that makes use of multiple data modalities and integrates agin...
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Main Authors: | Anastasiya Belyaeva, Louis Cammarata, Adityanarayanan Radhakrishnan, Chandler Squires, Karren Dai Yang, G. V. Shivashankar, Caroline Uhler |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2021
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Online Access: | https://doaj.org/article/0070bbeebfbc43a1a7a2f2bff257da7c |
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