Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells

Vito et al. investigated the effects of combination therapy in a TNBC tumor model and reported increased tumor-infiltrating lymphocytes that contributed to an improved response to immune checkpoint blockade. By depletion of circulating B cells prior to therapy, the authors showed a loss of therapeut...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alyssa Vito, Omar Salem, Nader El-Sayes, Ian P. MacFawn, Ana L. Portillo, Katy Milne, Danielle Harrington, Ali A. Ashkar, Yonghong Wan, Samuel T. Workenhe, Brad H. Nelson, Tullia C. Bruno, Karen L. Mossman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/05222c9ff4534f789861496bd23f86ca
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:05222c9ff4534f789861496bd23f86ca
record_format	dspace
spelling	oai:doaj.org-article:05222c9ff4534f789861496bd23f86ca2021-12-02T18:30:44ZImmune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells10.1038/s42003-021-02375-92399-3642https://doaj.org/article/05222c9ff4534f789861496bd23f86ca2021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02375-9https://doaj.org/toc/2399-3642Vito et al. investigated the effects of combination therapy in a TNBC tumor model and reported increased tumor-infiltrating lymphocytes that contributed to an improved response to immune checkpoint blockade. By depletion of circulating B cells prior to therapy, the authors showed a loss of therapeutic efficacy and simultaneous expansion of myeloid-derived suppressor cells.Alyssa VitoOmar SalemNader El-SayesIan P. MacFawnAna L. PortilloKaty MilneDanielle HarringtonAli A. AshkarYonghong WanSamuel T. WorkenheBrad H. NelsonTullia C. BrunoKaren L. MossmanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Alyssa Vito Omar Salem Nader El-Sayes Ian P. MacFawn Ana L. Portillo Katy Milne Danielle Harrington Ali A. Ashkar Yonghong Wan Samuel T. Workenhe Brad H. Nelson Tullia C. Bruno Karen L. Mossman Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells
description	Vito et al. investigated the effects of combination therapy in a TNBC tumor model and reported increased tumor-infiltrating lymphocytes that contributed to an improved response to immune checkpoint blockade. By depletion of circulating B cells prior to therapy, the authors showed a loss of therapeutic efficacy and simultaneous expansion of myeloid-derived suppressor cells.
format	article
author	Alyssa Vito Omar Salem Nader El-Sayes Ian P. MacFawn Ana L. Portillo Katy Milne Danielle Harrington Ali A. Ashkar Yonghong Wan Samuel T. Workenhe Brad H. Nelson Tullia C. Bruno Karen L. Mossman
author_facet	Alyssa Vito Omar Salem Nader El-Sayes Ian P. MacFawn Ana L. Portillo Katy Milne Danielle Harrington Ali A. Ashkar Yonghong Wan Samuel T. Workenhe Brad H. Nelson Tullia C. Bruno Karen L. Mossman
author_sort	Alyssa Vito
title	Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells
title_short	Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells
title_full	Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells
title_fullStr	Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells
title_full_unstemmed	Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells
title_sort	immune checkpoint blockade in triple negative breast cancer influenced by b cells through myeloid-derived suppressor cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/05222c9ff4534f789861496bd23f86ca
work_keys_str_mv	AT alyssavito immunecheckpointblockadeintriplenegativebreastcancerinfluencedbybcellsthroughmyeloidderivedsuppressorcells AT omarsalem immunecheckpointblockadeintriplenegativebreastcancerinfluencedbybcellsthroughmyeloidderivedsuppressorcells AT naderelsayes immunecheckpointblockadeintriplenegativebreastcancerinfluencedbybcellsthroughmyeloidderivedsuppressorcells AT ianpmacfawn immunecheckpointblockadeintriplenegativebreastcancerinfluencedbybcellsthroughmyeloidderivedsuppressorcells AT analportillo immunecheckpointblockadeintriplenegativebreastcancerinfluencedbybcellsthroughmyeloidderivedsuppressorcells AT katymilne immunecheckpointblockadeintriplenegativebreastcancerinfluencedbybcellsthroughmyeloidderivedsuppressorcells AT danielleharrington immunecheckpointblockadeintriplenegativebreastcancerinfluencedbybcellsthroughmyeloidderivedsuppressorcells AT aliaashkar immunecheckpointblockadeintriplenegativebreastcancerinfluencedbybcellsthroughmyeloidderivedsuppressorcells AT yonghongwan immunecheckpointblockadeintriplenegativebreastcancerinfluencedbybcellsthroughmyeloidderivedsuppressorcells AT samueltworkenhe immunecheckpointblockadeintriplenegativebreastcancerinfluencedbybcellsthroughmyeloidderivedsuppressorcells AT bradhnelson immunecheckpointblockadeintriplenegativebreastcancerinfluencedbybcellsthroughmyeloidderivedsuppressorcells AT tulliacbruno immunecheckpointblockadeintriplenegativebreastcancerinfluencedbybcellsthroughmyeloidderivedsuppressorcells AT karenlmossman immunecheckpointblockadeintriplenegativebreastcancerinfluencedbybcellsthroughmyeloidderivedsuppressorcells
_version_	1718377959614578688

Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells

Ejemplares similares