Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells

Vito et al. investigated the effects of combination therapy in a TNBC tumor model and reported increased tumor-infiltrating lymphocytes that contributed to an improved response to immune checkpoint blockade. By depletion of circulating B cells prior to therapy, the authors showed a loss of therapeut...

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Auteurs principaux:	Alyssa Vito, Omar Salem, Nader El-Sayes, Ian P. MacFawn, Ana L. Portillo, Katy Milne, Danielle Harrington, Ali A. Ashkar, Yonghong Wan, Samuel T. Workenhe, Brad H. Nelson, Tullia C. Bruno, Karen L. Mossman
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/05222c9ff4534f789861496bd23f86ca
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spelling	oai:doaj.org-article:05222c9ff4534f789861496bd23f86ca2021-12-02T18:30:44ZImmune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells10.1038/s42003-021-02375-92399-3642https://doaj.org/article/05222c9ff4534f789861496bd23f86ca2021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02375-9https://doaj.org/toc/2399-3642Vito et al. investigated the effects of combination therapy in a TNBC tumor model and reported increased tumor-infiltrating lymphocytes that contributed to an improved response to immune checkpoint blockade. By depletion of circulating B cells prior to therapy, the authors showed a loss of therapeutic efficacy and simultaneous expansion of myeloid-derived suppressor cells.Alyssa VitoOmar SalemNader El-SayesIan P. MacFawnAna L. PortilloKaty MilneDanielle HarringtonAli A. AshkarYonghong WanSamuel T. WorkenheBrad H. NelsonTullia C. BrunoKaren L. MossmanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Alyssa Vito Omar Salem Nader El-Sayes Ian P. MacFawn Ana L. Portillo Katy Milne Danielle Harrington Ali A. Ashkar Yonghong Wan Samuel T. Workenhe Brad H. Nelson Tullia C. Bruno Karen L. Mossman Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells
description	Vito et al. investigated the effects of combination therapy in a TNBC tumor model and reported increased tumor-infiltrating lymphocytes that contributed to an improved response to immune checkpoint blockade. By depletion of circulating B cells prior to therapy, the authors showed a loss of therapeutic efficacy and simultaneous expansion of myeloid-derived suppressor cells.
format	article
author	Alyssa Vito Omar Salem Nader El-Sayes Ian P. MacFawn Ana L. Portillo Katy Milne Danielle Harrington Ali A. Ashkar Yonghong Wan Samuel T. Workenhe Brad H. Nelson Tullia C. Bruno Karen L. Mossman
author_facet	Alyssa Vito Omar Salem Nader El-Sayes Ian P. MacFawn Ana L. Portillo Katy Milne Danielle Harrington Ali A. Ashkar Yonghong Wan Samuel T. Workenhe Brad H. Nelson Tullia C. Bruno Karen L. Mossman
author_sort	Alyssa Vito
title	Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells
title_short	Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells
title_full	Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells
title_fullStr	Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells
title_full_unstemmed	Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells
title_sort	immune checkpoint blockade in triple negative breast cancer influenced by b cells through myeloid-derived suppressor cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/05222c9ff4534f789861496bd23f86ca
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Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells

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