Eliciting the silent lucensomycin biosynthetic pathway in Streptomyces cyanogenus S136 via manipulation of the global regulatory gene adpA

Abstract Actinobacteria are among the most prolific sources of medically and agriculturally important compounds, derived from their biosynthetic gene clusters (BGCs) for specialized (secondary) pathways of metabolism. Genomics witnesses that the majority of actinobacterial BGCs are silent, most like...

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Autores principales: Oleksandr Yushchuk, Iryna Ostash, Eva Mösker, Iryna Vlasiuk, Maksym Deneka, Christian Rückert, Tobias Busche, Victor Fedorenko, Jörn Kalinowski, Roderich D. Süssmuth, Bohdan Ostash
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/057a7057442146c8ad1690394f59b75a
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