Eliciting the silent lucensomycin biosynthetic pathway in Streptomyces cyanogenus S136 via manipulation of the global regulatory gene adpA

Abstract Actinobacteria are among the most prolific sources of medically and agriculturally important compounds, derived from their biosynthetic gene clusters (BGCs) for specialized (secondary) pathways of metabolism. Genomics witnesses that the majority of actinobacterial BGCs are silent, most like...

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Main Authors: Oleksandr Yushchuk, Iryna Ostash, Eva Mösker, Iryna Vlasiuk, Maksym Deneka, Christian Rückert, Tobias Busche, Victor Fedorenko, Jörn Kalinowski, Roderich D. Süssmuth, Bohdan Ostash
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
R
Q
Online Access:https://doaj.org/article/057a7057442146c8ad1690394f59b75a
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