Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

In Parkinson’s disease (PD) the monomeric protein alpha-synuclein (aSyn) misfolds and aggregates into insoluble fibrils. Here the authors use NMR measurements and hydrogen–deuterium exchange mass spectrometry and find that the more solvent exposed the N-terminus of aSyn is, the more aggregation pron...

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Main Authors: Amberley D. Stephens, Maria Zacharopoulou, Rani Moons, Giuliana Fusco, Neeleema Seetaloo, Anass Chiki, Philippa J. Woodhams, Ioanna Mela, Hilal A. Lashuel, Jonathan J. Phillips, Alfonso De Simone, Frank Sobott, Gabriele S. Kaminski Schierle
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/06df908e29ff4c6a9479ca48a333babb
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https://doaj.org/article/06df908e29ff4c6a9479ca48a333babb

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