Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of <named-content content-type="genus-species">Neisseria gonorrhoeae</named-content> Possessing a Mosaic-Like <italic toggle="yes">mtr</italic> Efflux Pump Locus

Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of <named-content content-type="genus-species">Neisseria gonorrhoeae</named-content> Possessing a Mosaic-Like <italic toggle="yes">mtr</italic> Efflux Pump Locus

ABSTRACT Recent reports suggest that mosaic-like sequences within the mtr (multiple transferable resistance) efflux pump locus of Neisseria gonorrhoeae, likely originating from commensal Neisseria sp. by transformation, can increase the ability of gonococci to resist structurally diverse antimicrobi...

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Bibliographic Details
Main Authors: Corinne E. Rouquette-Loughlin, Jennifer L. Reimche, Jacqueline T. Balthazar, Vijaya Dhulipala, Kim M. Gernert, Ellen N. Kersh, Cau D. Pham, Kevin Pettus, A. Jeanine Abrams, David L. Trees, Sancta St Cyr, William M. Shafer
Format: article
Language:EN
Published: American Society for Microbiology 2018
Subjects:
antibiotic resistance
efflux
gonorrhea
molecular genetics
transformation
Microbiology
QR1-502
Online Access:https://doaj.org/article/0768313d52f94a4392f3650a97098160
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https://doaj.org/article/0768313d52f94a4392f3650a97098160

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