A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

Benzoxaboroles have been shown to be active against different pathogens. Here, the authors show that the benzoxaborole AN3661 inhibitsPlasmodium falciparum in vitroand in mouse models, and identify a homologue of a mammalian cleavage and polyadenylation specificity factor as a drug target.

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Autores principales:	Ebere Sonoiki, Caroline L. Ng, Marcus C. S. Lee, Denghui Guo, Yong-Kang Zhang, Yasheen Zhou, M. R. K. Alley, Vida Ahyong, Laura M. Sanz, Maria Jose Lafuente-Monasterio, Chen Dong, Patrick G. Schupp, Jiri Gut, Jenny Legac, Roland A. Cooper, Francisco-Javier Gamo, Joseph DeRisi, Yvonne R. Freund, David A. Fidock, Philip J. Rosenthal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0a61f14362894ce98b395b6ccf63a199
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spelling	oai:doaj.org-article:0a61f14362894ce98b395b6ccf63a1992021-12-02T15:39:02ZA potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue10.1038/ncomms145742041-1723https://doaj.org/article/0a61f14362894ce98b395b6ccf63a1992017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14574https://doaj.org/toc/2041-1723Benzoxaboroles have been shown to be active against different pathogens. Here, the authors show that the benzoxaborole AN3661 inhibitsPlasmodium falciparum in vitroand in mouse models, and identify a homologue of a mammalian cleavage and polyadenylation specificity factor as a drug target.Ebere SonoikiCaroline L. NgMarcus C. S. LeeDenghui GuoYong-Kang ZhangYasheen ZhouM. R. K. AlleyVida AhyongLaura M. SanzMaria Jose Lafuente-MonasterioChen DongPatrick G. SchuppJiri GutJenny LegacRoland A. CooperFrancisco-Javier GamoJoseph DeRisiYvonne R. FreundDavid A. FidockPhilip J. RosenthalNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ebere Sonoiki Caroline L. Ng Marcus C. S. Lee Denghui Guo Yong-Kang Zhang Yasheen Zhou M. R. K. Alley Vida Ahyong Laura M. Sanz Maria Jose Lafuente-Monasterio Chen Dong Patrick G. Schupp Jiri Gut Jenny Legac Roland A. Cooper Francisco-Javier Gamo Joseph DeRisi Yvonne R. Freund David A. Fidock Philip J. Rosenthal A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
description	Benzoxaboroles have been shown to be active against different pathogens. Here, the authors show that the benzoxaborole AN3661 inhibitsPlasmodium falciparum in vitroand in mouse models, and identify a homologue of a mammalian cleavage and polyadenylation specificity factor as a drug target.
format	article
author	Ebere Sonoiki Caroline L. Ng Marcus C. S. Lee Denghui Guo Yong-Kang Zhang Yasheen Zhou M. R. K. Alley Vida Ahyong Laura M. Sanz Maria Jose Lafuente-Monasterio Chen Dong Patrick G. Schupp Jiri Gut Jenny Legac Roland A. Cooper Francisco-Javier Gamo Joseph DeRisi Yvonne R. Freund David A. Fidock Philip J. Rosenthal
author_facet	Ebere Sonoiki Caroline L. Ng Marcus C. S. Lee Denghui Guo Yong-Kang Zhang Yasheen Zhou M. R. K. Alley Vida Ahyong Laura M. Sanz Maria Jose Lafuente-Monasterio Chen Dong Patrick G. Schupp Jiri Gut Jenny Legac Roland A. Cooper Francisco-Javier Gamo Joseph DeRisi Yvonne R. Freund David A. Fidock Philip J. Rosenthal
author_sort	Ebere Sonoiki
title	A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
title_short	A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
title_full	A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
title_fullStr	A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
title_full_unstemmed	A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
title_sort	potent antimalarial benzoxaborole targets a plasmodium falciparum cleavage and polyadenylation specificity factor homologue
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0a61f14362894ce98b395b6ccf63a199
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A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

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