Dramatic activation of an antibody by a single amino acid change in framework

Abstract Antibody function is typically entirely dictated by the Complementarity Determining Regions (CDRs) that directly bind to the antigen, while the framework region acts as a scaffold for the CDRs and maintains overall structure of the variable domain. We recently reported that the rabbit monoc...

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Autores principales: Wei-Ching Liang, Jianping Yin, Patrick Lupardus, Jianhuan Zhang, Kelly M. Loyet, Jawahar Sudhamsu, Yan Wu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/0b851df1980f44c9ad9fd78eb3510ab2
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