Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice

Several human coronaviruses (CoV) have been proposed to emerge from bats but evidence of direct bat-to-human transmission is slim. In this work, the authors isolate a MERS-related CoV strain directly from bats and show that it infects target cells in vitro and engineered mice through the human DDP4...

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Autores principales:	Susanna K. P. Lau, Rachel Y. Y. Fan, Longchao Zhu, Kenneth S. M. Li, Antonio C. P. Wong, Hayes K. H. Luk, Emily Y. M. Wong, Carol S. F. Lam, George C. S. Lo, Joshua Fung, Zirong He, Felix C. H. Fok, Rex K. H. Au-Yeung, Libiao Zhang, Kin-Hang Kok, Kwok-Yung Yuen, Patrick C. Y. Woo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e0c505e69d14f01826f70c19f4cde59
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spelling	oai:doaj.org-article:0e0c505e69d14f01826f70c19f4cde592021-12-02T14:11:57ZIsolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice10.1038/s41467-020-20458-92041-1723https://doaj.org/article/0e0c505e69d14f01826f70c19f4cde592021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20458-9https://doaj.org/toc/2041-1723Several human coronaviruses (CoV) have been proposed to emerge from bats but evidence of direct bat-to-human transmission is slim. In this work, the authors isolate a MERS-related CoV strain directly from bats and show that it infects target cells in vitro and engineered mice through the human DDP4 receptor.Susanna K. P. LauRachel Y. Y. FanLongchao ZhuKenneth S. M. LiAntonio C. P. WongHayes K. H. LukEmily Y. M. WongCarol S. F. LamGeorge C. S. LoJoshua FungZirong HeFelix C. H. FokRex K. H. Au-YeungLibiao ZhangKin-Hang KokKwok-Yung YuenPatrick C. Y. WooNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Susanna K. P. Lau Rachel Y. Y. Fan Longchao Zhu Kenneth S. M. Li Antonio C. P. Wong Hayes K. H. Luk Emily Y. M. Wong Carol S. F. Lam George C. S. Lo Joshua Fung Zirong He Felix C. H. Fok Rex K. H. Au-Yeung Libiao Zhang Kin-Hang Kok Kwok-Yung Yuen Patrick C. Y. Woo Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice
description	Several human coronaviruses (CoV) have been proposed to emerge from bats but evidence of direct bat-to-human transmission is slim. In this work, the authors isolate a MERS-related CoV strain directly from bats and show that it infects target cells in vitro and engineered mice through the human DDP4 receptor.
format	article
author	Susanna K. P. Lau Rachel Y. Y. Fan Longchao Zhu Kenneth S. M. Li Antonio C. P. Wong Hayes K. H. Luk Emily Y. M. Wong Carol S. F. Lam George C. S. Lo Joshua Fung Zirong He Felix C. H. Fok Rex K. H. Au-Yeung Libiao Zhang Kin-Hang Kok Kwok-Yung Yuen Patrick C. Y. Woo
author_facet	Susanna K. P. Lau Rachel Y. Y. Fan Longchao Zhu Kenneth S. M. Li Antonio C. P. Wong Hayes K. H. Luk Emily Y. M. Wong Carol S. F. Lam George C. S. Lo Joshua Fung Zirong He Felix C. H. Fok Rex K. H. Au-Yeung Libiao Zhang Kin-Hang Kok Kwok-Yung Yuen Patrick C. Y. Woo
author_sort	Susanna K. P. Lau
title	Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice
title_short	Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice
title_full	Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice
title_fullStr	Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice
title_full_unstemmed	Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice
title_sort	isolation of mers-related coronavirus from lesser bamboo bats that uses dpp4 and infects human-dpp4-transgenic mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0e0c505e69d14f01826f70c19f4cde59
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Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice

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