Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice

Several human coronaviruses (CoV) have been proposed to emerge from bats but evidence of direct bat-to-human transmission is slim. In this work, the authors isolate a MERS-related CoV strain directly from bats and show that it infects target cells in vitro and engineered mice through the human DDP4...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Susanna K. P. Lau, Rachel Y. Y. Fan, Longchao Zhu, Kenneth S. M. Li, Antonio C. P. Wong, Hayes K. H. Luk, Emily Y. M. Wong, Carol S. F. Lam, George C. S. Lo, Joshua Fung, Zirong He, Felix C. H. Fok, Rex K. H. Au-Yeung, Libiao Zhang, Kin-Hang Kok, Kwok-Yung Yuen, Patrick C. Y. Woo
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/0e0c505e69d14f01826f70c19f4cde59
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

id	oai:doaj.org-article:0e0c505e69d14f01826f70c19f4cde59
record_format	dspace
spelling	oai:doaj.org-article:0e0c505e69d14f01826f70c19f4cde592021-12-02T14:11:57ZIsolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice10.1038/s41467-020-20458-92041-1723https://doaj.org/article/0e0c505e69d14f01826f70c19f4cde592021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20458-9https://doaj.org/toc/2041-1723Several human coronaviruses (CoV) have been proposed to emerge from bats but evidence of direct bat-to-human transmission is slim. In this work, the authors isolate a MERS-related CoV strain directly from bats and show that it infects target cells in vitro and engineered mice through the human DDP4 receptor.Susanna K. P. LauRachel Y. Y. FanLongchao ZhuKenneth S. M. LiAntonio C. P. WongHayes K. H. LukEmily Y. M. WongCarol S. F. LamGeorge C. S. LoJoshua FungZirong HeFelix C. H. FokRex K. H. Au-YeungLibiao ZhangKin-Hang KokKwok-Yung YuenPatrick C. Y. WooNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Susanna K. P. Lau Rachel Y. Y. Fan Longchao Zhu Kenneth S. M. Li Antonio C. P. Wong Hayes K. H. Luk Emily Y. M. Wong Carol S. F. Lam George C. S. Lo Joshua Fung Zirong He Felix C. H. Fok Rex K. H. Au-Yeung Libiao Zhang Kin-Hang Kok Kwok-Yung Yuen Patrick C. Y. Woo Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice
description	Several human coronaviruses (CoV) have been proposed to emerge from bats but evidence of direct bat-to-human transmission is slim. In this work, the authors isolate a MERS-related CoV strain directly from bats and show that it infects target cells in vitro and engineered mice through the human DDP4 receptor.
format	article
author	Susanna K. P. Lau Rachel Y. Y. Fan Longchao Zhu Kenneth S. M. Li Antonio C. P. Wong Hayes K. H. Luk Emily Y. M. Wong Carol S. F. Lam George C. S. Lo Joshua Fung Zirong He Felix C. H. Fok Rex K. H. Au-Yeung Libiao Zhang Kin-Hang Kok Kwok-Yung Yuen Patrick C. Y. Woo
author_facet	Susanna K. P. Lau Rachel Y. Y. Fan Longchao Zhu Kenneth S. M. Li Antonio C. P. Wong Hayes K. H. Luk Emily Y. M. Wong Carol S. F. Lam George C. S. Lo Joshua Fung Zirong He Felix C. H. Fok Rex K. H. Au-Yeung Libiao Zhang Kin-Hang Kok Kwok-Yung Yuen Patrick C. Y. Woo
author_sort	Susanna K. P. Lau
title	Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice
title_short	Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice
title_full	Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice
title_fullStr	Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice
title_full_unstemmed	Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice
title_sort	isolation of mers-related coronavirus from lesser bamboo bats that uses dpp4 and infects human-dpp4-transgenic mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0e0c505e69d14f01826f70c19f4cde59
work_keys_str_mv	AT susannakplau isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice AT rachelyyfan isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice AT longchaozhu isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice AT kennethsmli isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice AT antoniocpwong isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice AT hayeskhluk isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice AT emilyymwong isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice AT carolsflam isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice AT georgecslo isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice AT joshuafung isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice AT zironghe isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice AT felixchfok isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice AT rexkhauyeung isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice AT libiaozhang isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice AT kinhangkok isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice AT kwokyungyuen isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice AT patrickcywoo isolationofmersrelatedcoronavirusfromlesserbamboobatsthatusesdpp4andinfectshumandpp4transgenicmice
_version_	1718391827494600704

Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice

Documents similaires