Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus

Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus

CRISPR-Cas9 has rapidly become a common molecular biology tool for modifying genomes and has been modified to generate single-strand nicks as well as double-strand breaks. Here the authors explore the DNA repair pathways activated by the different variants of Cas9.

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Auteurs principaux: Anne Bothmer, Tanushree Phadke, Luis A. Barrera, Carrie M Margulies, Christina S. Lee, Frank Buquicchio, Sean Moss, Hayat S. Abdulkerim, William Selleck, Hariharan Jayaram, Vic E. Myer, Cecilia Cotta-Ramusino
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Science
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Accès en ligne:https://doaj.org/article/0e7ab32becea4c83bb655f0d5113f731
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https://doaj.org/article/0e7ab32becea4c83bb655f0d5113f731

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