Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus

CRISPR-Cas9 has rapidly become a common molecular biology tool for modifying genomes and has been modified to generate single-strand nicks as well as double-strand breaks. Here the authors explore the DNA repair pathways activated by the different variants of Cas9.

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Autores principales:	Anne Bothmer, Tanushree Phadke, Luis A. Barrera, Carrie M Margulies, Christina S. Lee, Frank Buquicchio, Sean Moss, Hayat S. Abdulkerim, William Selleck, Hariharan Jayaram, Vic E. Myer, Cecilia Cotta-Ramusino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e7ab32becea4c83bb655f0d5113f731
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spelling	oai:doaj.org-article:0e7ab32becea4c83bb655f0d5113f7312021-12-02T14:42:17ZCharacterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus10.1038/ncomms139052041-1723https://doaj.org/article/0e7ab32becea4c83bb655f0d5113f7312017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13905https://doaj.org/toc/2041-1723CRISPR-Cas9 has rapidly become a common molecular biology tool for modifying genomes and has been modified to generate single-strand nicks as well as double-strand breaks. Here the authors explore the DNA repair pathways activated by the different variants of Cas9.Anne BothmerTanushree PhadkeLuis A. BarreraCarrie M MarguliesChristina S. LeeFrank BuquicchioSean MossHayat S. AbdulkerimWilliam SelleckHariharan JayaramVic E. MyerCecilia Cotta-RamusinoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anne Bothmer Tanushree Phadke Luis A. Barrera Carrie M Margulies Christina S. Lee Frank Buquicchio Sean Moss Hayat S. Abdulkerim William Selleck Hariharan Jayaram Vic E. Myer Cecilia Cotta-Ramusino Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus
description	CRISPR-Cas9 has rapidly become a common molecular biology tool for modifying genomes and has been modified to generate single-strand nicks as well as double-strand breaks. Here the authors explore the DNA repair pathways activated by the different variants of Cas9.
format	article
author	Anne Bothmer Tanushree Phadke Luis A. Barrera Carrie M Margulies Christina S. Lee Frank Buquicchio Sean Moss Hayat S. Abdulkerim William Selleck Hariharan Jayaram Vic E. Myer Cecilia Cotta-Ramusino
author_facet	Anne Bothmer Tanushree Phadke Luis A. Barrera Carrie M Margulies Christina S. Lee Frank Buquicchio Sean Moss Hayat S. Abdulkerim William Selleck Hariharan Jayaram Vic E. Myer Cecilia Cotta-Ramusino
author_sort	Anne Bothmer
title	Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus
title_short	Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus
title_full	Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus
title_fullStr	Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus
title_full_unstemmed	Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus
title_sort	characterization of the interplay between dna repair and crispr/cas9-induced dna lesions at an endogenous locus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0e7ab32becea4c83bb655f0d5113f731
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Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus

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