A modular degron library for synthetic circuits in mammalian cells

One method of controlling protein degradation is through the use of degrons. Here the authors present a toolbox of characterised degrons as a library to fine-tune biological gene-expression systems. Its application is demonstrated by a set of tunable synthetic pulse generators in mammalian cells.

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Autores principales: Hélène Chassin, Marius Müller, Marcel Tigges, Leo Scheller, Moritz Lang, Martin Fussenegger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/0f1eb5b8cee8453291b16d5e5bb23e82
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