A modular degron library for synthetic circuits in mammalian cells

A modular degron library for synthetic circuits in mammalian cells

One method of controlling protein degradation is through the use of degrons. Here the authors present a toolbox of characterised degrons as a library to fine-tune biological gene-expression systems. Its application is demonstrated by a set of tunable synthetic pulse generators in mammalian cells.

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Autores principales: Hélène Chassin, Marius Müller, Marcel Tigges, Leo Scheller, Moritz Lang, Martin Fussenegger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/0f1eb5b8cee8453291b16d5e5bb23e82
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spelling oai:doaj.org-article:0f1eb5b8cee8453291b16d5e5bb23e822021-12-02T15:35:54ZA modular degron library for synthetic circuits in mammalian cells10.1038/s41467-019-09974-52041-1723https://doaj.org/article/0f1eb5b8cee8453291b16d5e5bb23e822019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09974-5https://doaj.org/toc/2041-1723One method of controlling protein degradation is through the use of degrons. Here the authors present a toolbox of characterised degrons as a library to fine-tune biological gene-expression systems. Its application is demonstrated by a set of tunable synthetic pulse generators in mammalian cells.Hélène ChassinMarius MüllerMarcel TiggesLeo SchellerMoritz LangMartin FusseneggerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hélène Chassin
Marius Müller
Marcel Tigges
Leo Scheller
Moritz Lang
Martin Fussenegger
A modular degron library for synthetic circuits in mammalian cells
description One method of controlling protein degradation is through the use of degrons. Here the authors present a toolbox of characterised degrons as a library to fine-tune biological gene-expression systems. Its application is demonstrated by a set of tunable synthetic pulse generators in mammalian cells.
format article
author Hélène Chassin
Marius Müller
Marcel Tigges
Leo Scheller
Moritz Lang
Martin Fussenegger
author_facet Hélène Chassin
Marius Müller
Marcel Tigges
Leo Scheller
Moritz Lang
Martin Fussenegger
author_sort Hélène Chassin
title A modular degron library for synthetic circuits in mammalian cells
title_short A modular degron library for synthetic circuits in mammalian cells
title_full A modular degron library for synthetic circuits in mammalian cells
title_fullStr A modular degron library for synthetic circuits in mammalian cells
title_full_unstemmed A modular degron library for synthetic circuits in mammalian cells
title_sort modular degron library for synthetic circuits in mammalian cells
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/0f1eb5b8cee8453291b16d5e5bb23e82
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