Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming

Current cellular rewiring designs are typically tailored to detect single inputs. Here the authors present GEARs that function independently of engineered receptor/reporter systems and directly reroute endogenous signaling pathways to alternative genomic loci using dCas9-directed gene expression.

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Auteurs principaux: Krzysztof Krawczyk, Leo Scheller, Hyojin Kim, Martin Fussenegger
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/13853f7a87f14e18bd15991f24ec4e78
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