Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming

Current cellular rewiring designs are typically tailored to detect single inputs. Here the authors present GEARs that function independently of engineered receptor/reporter systems and directly reroute endogenous signaling pathways to alternative genomic loci using dCas9-directed gene expression.

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Autores principales:	Krzysztof Krawczyk, Leo Scheller, Hyojin Kim, Martin Fussenegger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13853f7a87f14e18bd15991f24ec4e78
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spelling	oai:doaj.org-article:13853f7a87f14e18bd15991f24ec4e782021-12-02T14:40:40ZRewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming10.1038/s41467-020-14397-82041-1723https://doaj.org/article/13853f7a87f14e18bd15991f24ec4e782020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14397-8https://doaj.org/toc/2041-1723Current cellular rewiring designs are typically tailored to detect single inputs. Here the authors present GEARs that function independently of engineered receptor/reporter systems and directly reroute endogenous signaling pathways to alternative genomic loci using dCas9-directed gene expression.Krzysztof KrawczykLeo SchellerHyojin KimMartin FusseneggerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Krzysztof Krawczyk Leo Scheller Hyojin Kim Martin Fussenegger Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming
description	Current cellular rewiring designs are typically tailored to detect single inputs. Here the authors present GEARs that function independently of engineered receptor/reporter systems and directly reroute endogenous signaling pathways to alternative genomic loci using dCas9-directed gene expression.
format	article
author	Krzysztof Krawczyk Leo Scheller Hyojin Kim Martin Fussenegger
author_facet	Krzysztof Krawczyk Leo Scheller Hyojin Kim Martin Fussenegger
author_sort	Krzysztof Krawczyk
title	Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming
title_short	Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming
title_full	Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming
title_fullStr	Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming
title_full_unstemmed	Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming
title_sort	rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/13853f7a87f14e18bd15991f24ec4e78
work_keys_str_mv	AT krzysztofkrawczyk rewiringofendogenoussignalingpathwaystogenomictargetsfortherapeuticcellreprogramming AT leoscheller rewiringofendogenoussignalingpathwaystogenomictargetsfortherapeuticcellreprogramming AT hyojinkim rewiringofendogenoussignalingpathwaystogenomictargetsfortherapeuticcellreprogramming AT martinfussenegger rewiringofendogenoussignalingpathwaystogenomictargetsfortherapeuticcellreprogramming
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Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming

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