ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer

Non-small cell lung cancer (NSCLC) is often associated with metastasis to the lungs. Here, the authors perform independent screens and identify NuRD as a co-repressor of ZEB1, and demonstrate TBC1D2b as a downstream target of ZEB1/NuRD complex regulating NSCLC metastasis.

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Autores principales:	Roxsan Manshouri, Etienne Coyaud, Samrat T. Kundu, David H. Peng, Sabrina A. Stratton, Kendra Alton, Rakhee Bajaj, Jared J. Fradette, Rosalba Minelli, Michael D. Peoples, Alessandro Carugo, Fengju Chen, Christopher Bristow, Jeffrey J. Kovacs, Michelle C. Barton, Tim Heffernan, Chad J. Creighton, Brian Raught, Don L. Gibbons
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/175dfc318ac14591a1188315ed141a14
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spelling	oai:doaj.org-article:175dfc318ac14591a1188315ed141a142021-12-02T16:57:43ZZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer10.1038/s41467-019-12832-z2041-1723https://doaj.org/article/175dfc318ac14591a1188315ed141a142019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12832-zhttps://doaj.org/toc/2041-1723Non-small cell lung cancer (NSCLC) is often associated with metastasis to the lungs. Here, the authors perform independent screens and identify NuRD as a co-repressor of ZEB1, and demonstrate TBC1D2b as a downstream target of ZEB1/NuRD complex regulating NSCLC metastasis.Roxsan ManshouriEtienne CoyaudSamrat T. KunduDavid H. PengSabrina A. StrattonKendra AltonRakhee BajajJared J. FradetteRosalba MinelliMichael D. PeoplesAlessandro CarugoFengju ChenChristopher BristowJeffrey J. KovacsMichelle C. BartonTim HeffernanChad J. CreightonBrian RaughtDon L. GibbonsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roxsan Manshouri Etienne Coyaud Samrat T. Kundu David H. Peng Sabrina A. Stratton Kendra Alton Rakhee Bajaj Jared J. Fradette Rosalba Minelli Michael D. Peoples Alessandro Carugo Fengju Chen Christopher Bristow Jeffrey J. Kovacs Michelle C. Barton Tim Heffernan Chad J. Creighton Brian Raught Don L. Gibbons ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer
description	Non-small cell lung cancer (NSCLC) is often associated with metastasis to the lungs. Here, the authors perform independent screens and identify NuRD as a co-repressor of ZEB1, and demonstrate TBC1D2b as a downstream target of ZEB1/NuRD complex regulating NSCLC metastasis.
format	article
author	Roxsan Manshouri Etienne Coyaud Samrat T. Kundu David H. Peng Sabrina A. Stratton Kendra Alton Rakhee Bajaj Jared J. Fradette Rosalba Minelli Michael D. Peoples Alessandro Carugo Fengju Chen Christopher Bristow Jeffrey J. Kovacs Michelle C. Barton Tim Heffernan Chad J. Creighton Brian Raught Don L. Gibbons
author_facet	Roxsan Manshouri Etienne Coyaud Samrat T. Kundu David H. Peng Sabrina A. Stratton Kendra Alton Rakhee Bajaj Jared J. Fradette Rosalba Minelli Michael D. Peoples Alessandro Carugo Fengju Chen Christopher Bristow Jeffrey J. Kovacs Michelle C. Barton Tim Heffernan Chad J. Creighton Brian Raught Don L. Gibbons
author_sort	Roxsan Manshouri
title	ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer
title_short	ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer
title_full	ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer
title_fullStr	ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer
title_full_unstemmed	ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer
title_sort	zeb1/nurd complex suppresses tbc1d2b to stimulate e-cadherin internalization and promote metastasis in lung cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/175dfc318ac14591a1188315ed141a14
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ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer

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