SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4
SRPK1, a kinase involved in splicing regulation, is a potential therapeutic target for AML patients. Here, the authors show that SRPK1 inhibition changes isoform levels of key epigenetic regulators, including BRD4, and it has anti-tumor effects specifically against MLL-rearranged AML cells.
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Nature Portfolio
2018
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| Acceso en línea: | https://doaj.org/article/1853a1ced0ff46dfaf75bec9896c8581 |
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oai:doaj.org-article:1853a1ced0ff46dfaf75bec9896c85812021-12-02T14:40:31ZSRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD410.1038/s41467-018-07620-02041-1723https://doaj.org/article/1853a1ced0ff46dfaf75bec9896c85812018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07620-0https://doaj.org/toc/2041-1723SRPK1, a kinase involved in splicing regulation, is a potential therapeutic target for AML patients. Here, the authors show that SRPK1 inhibition changes isoform levels of key epigenetic regulators, including BRD4, and it has anti-tumor effects specifically against MLL-rearranged AML cells.Konstantinos TzelepisEtienne De BraekeleerDemetrios AsprisIsaia BarbieriM. S. VijayabaskarWen-Hsin LiuMalgorzata GozdeckaEmmanouil MetzakopianHamish D. ToopMonika DudekSamuel C. RobsonFrancisco Hermida-PradoYu Hsuen YangRoya Babaei-JadidiDimitrios A. GaryfallosHannes PonstinglJoao M. L. DiasPaolo GallipoliMichael SeilerSilvia BuonamiciBinje VickAndrew J. BannisterRoland RadRab K. PrinjhaJohn C. MarioniBrian HuntlyJennifer BatsonJonathan C. MorrisCristina PinaAllan BradleyIrmela JeremiasDavid O. BatesKosuke YusaTony KouzaridesGeorge S. VassiliouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Konstantinos Tzelepis Etienne De Braekeleer Demetrios Aspris Isaia Barbieri M. S. Vijayabaskar Wen-Hsin Liu Malgorzata Gozdecka Emmanouil Metzakopian Hamish D. Toop Monika Dudek Samuel C. Robson Francisco Hermida-Prado Yu Hsuen Yang Roya Babaei-Jadidi Dimitrios A. Garyfallos Hannes Ponstingl Joao M. L. Dias Paolo Gallipoli Michael Seiler Silvia Buonamici Binje Vick Andrew J. Bannister Roland Rad Rab K. Prinjha John C. Marioni Brian Huntly Jennifer Batson Jonathan C. Morris Cristina Pina Allan Bradley Irmela Jeremias David O. Bates Kosuke Yusa Tony Kouzarides George S. Vassiliou SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 |
| description |
SRPK1, a kinase involved in splicing regulation, is a potential therapeutic target for AML patients. Here, the authors show that SRPK1 inhibition changes isoform levels of key epigenetic regulators, including BRD4, and it has anti-tumor effects specifically against MLL-rearranged AML cells. |
| format |
article |
| author |
Konstantinos Tzelepis Etienne De Braekeleer Demetrios Aspris Isaia Barbieri M. S. Vijayabaskar Wen-Hsin Liu Malgorzata Gozdecka Emmanouil Metzakopian Hamish D. Toop Monika Dudek Samuel C. Robson Francisco Hermida-Prado Yu Hsuen Yang Roya Babaei-Jadidi Dimitrios A. Garyfallos Hannes Ponstingl Joao M. L. Dias Paolo Gallipoli Michael Seiler Silvia Buonamici Binje Vick Andrew J. Bannister Roland Rad Rab K. Prinjha John C. Marioni Brian Huntly Jennifer Batson Jonathan C. Morris Cristina Pina Allan Bradley Irmela Jeremias David O. Bates Kosuke Yusa Tony Kouzarides George S. Vassiliou |
| author_facet |
Konstantinos Tzelepis Etienne De Braekeleer Demetrios Aspris Isaia Barbieri M. S. Vijayabaskar Wen-Hsin Liu Malgorzata Gozdecka Emmanouil Metzakopian Hamish D. Toop Monika Dudek Samuel C. Robson Francisco Hermida-Prado Yu Hsuen Yang Roya Babaei-Jadidi Dimitrios A. Garyfallos Hannes Ponstingl Joao M. L. Dias Paolo Gallipoli Michael Seiler Silvia Buonamici Binje Vick Andrew J. Bannister Roland Rad Rab K. Prinjha John C. Marioni Brian Huntly Jennifer Batson Jonathan C. Morris Cristina Pina Allan Bradley Irmela Jeremias David O. Bates Kosuke Yusa Tony Kouzarides George S. Vassiliou |
| author_sort |
Konstantinos Tzelepis |
| title |
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 |
| title_short |
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 |
| title_full |
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 |
| title_fullStr |
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 |
| title_full_unstemmed |
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 |
| title_sort |
srpk1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including brd4 |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/1853a1ced0ff46dfaf75bec9896c8581 |
| work_keys_str_mv |
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