Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens

The invariant αβTCR of type I NKT cells recognizes a lipid α-GalCer presented by CD1d. Here the authors describe atypical α-GalCer-reactive NKT cells with diverse TCRs, which bind to CD1d-α-GalCer in a manner distinct from type I NKT cells, thus unveiling greater diversity in lipid antigen recogniti...

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Autores principales:	Jérôme Le Nours, T. Praveena, Daniel G. Pellicci, Nicholas A. Gherardin, Fiona J. Ross, Ricky T. Lim, Gurdyal S. Besra, Santosh Keshipeddy, Stewart K. Richardson, Amy R. Howell, Stephanie Gras, Dale I. Godfrey, Jamie Rossjohn, Adam P. Uldrich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/19f35c34e90047c3a1089ce7f064778b
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spelling	oai:doaj.org-article:19f35c34e90047c3a1089ce7f064778b2021-12-02T16:57:00ZAtypical natural killer T-cell receptor recognition of CD1d–lipid antigens10.1038/ncomms105702041-1723https://doaj.org/article/19f35c34e90047c3a1089ce7f064778b2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10570https://doaj.org/toc/2041-1723The invariant αβTCR of type I NKT cells recognizes a lipid α-GalCer presented by CD1d. Here the authors describe atypical α-GalCer-reactive NKT cells with diverse TCRs, which bind to CD1d-α-GalCer in a manner distinct from type I NKT cells, thus unveiling greater diversity in lipid antigen recognition.Jérôme Le NoursT. PraveenaDaniel G. PellicciNicholas A. GherardinFiona J. RossRicky T. LimGurdyal S. BesraSantosh KeshipeddyStewart K. RichardsonAmy R. HowellStephanie GrasDale I. GodfreyJamie RossjohnAdam P. UldrichNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jérôme Le Nours T. Praveena Daniel G. Pellicci Nicholas A. Gherardin Fiona J. Ross Ricky T. Lim Gurdyal S. Besra Santosh Keshipeddy Stewart K. Richardson Amy R. Howell Stephanie Gras Dale I. Godfrey Jamie Rossjohn Adam P. Uldrich Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens
description	The invariant αβTCR of type I NKT cells recognizes a lipid α-GalCer presented by CD1d. Here the authors describe atypical α-GalCer-reactive NKT cells with diverse TCRs, which bind to CD1d-α-GalCer in a manner distinct from type I NKT cells, thus unveiling greater diversity in lipid antigen recognition.
format	article
author	Jérôme Le Nours T. Praveena Daniel G. Pellicci Nicholas A. Gherardin Fiona J. Ross Ricky T. Lim Gurdyal S. Besra Santosh Keshipeddy Stewart K. Richardson Amy R. Howell Stephanie Gras Dale I. Godfrey Jamie Rossjohn Adam P. Uldrich
author_facet	Jérôme Le Nours T. Praveena Daniel G. Pellicci Nicholas A. Gherardin Fiona J. Ross Ricky T. Lim Gurdyal S. Besra Santosh Keshipeddy Stewart K. Richardson Amy R. Howell Stephanie Gras Dale I. Godfrey Jamie Rossjohn Adam P. Uldrich
author_sort	Jérôme Le Nours
title	Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens
title_short	Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens
title_full	Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens
title_fullStr	Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens
title_full_unstemmed	Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens
title_sort	atypical natural killer t-cell receptor recognition of cd1d–lipid antigens
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/19f35c34e90047c3a1089ce7f064778b
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Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens

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