Efficient biosynthesis of nucleoside cytokinin angustmycin A containing an unusual sugar system

Angustmycin A is a nucleoside antibiotic having anti-mycobacterial and cytokinin activities. Here, the authors report the whole pathway leading to angustmycin A biosynthesis in Streptomyces and achieve the heterologous production of angustmycin A in E. coli.

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Autores principales: Le Yu, Wenting Zhou, Yixuan She, Hongmin Ma, You-Sheng Cai, Ming Jiang, Zixin Deng, Neil P. J. Price, Wenqing Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/1a017a78f5e242bfab6c97b66db75c86
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