BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes

BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes

Bone morphogenetic protein (BMP) maintains intestinal homeostasis by restricting its hyperproliferation but whether it directly regulates the stem cells is unknown. Here the authors show that BMP constrains the Lgr5+stem cell expansion under both homeostatic and injury conditions through Smad-mediat...

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Autores principales: Zhen Qi, Yehua Li, Bing Zhao, Chi Xu, Yuan Liu, Haonan Li, Bingjie Zhang, Xinquan Wang, Xiao Yang, Wei Xie, Baojie Li, Jing-Dong Jackie Han, Ye-Guang Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/1cfafbf39370423c97491755711f11d9
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spelling oai:doaj.org-article:1cfafbf39370423c97491755711f11d92021-12-02T17:06:19ZBMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes10.1038/ncomms138242041-1723https://doaj.org/article/1cfafbf39370423c97491755711f11d92017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13824https://doaj.org/toc/2041-1723Bone morphogenetic protein (BMP) maintains intestinal homeostasis by restricting its hyperproliferation but whether it directly regulates the stem cells is unknown. Here the authors show that BMP constrains the Lgr5+stem cell expansion under both homeostatic and injury conditions through Smad-mediated repression of stem cell signature genes.Zhen QiYehua LiBing ZhaoChi XuYuan LiuHaonan LiBingjie ZhangXinquan WangXiao YangWei XieBaojie LiJing-Dong Jackie HanYe-Guang ChenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhen Qi
Yehua Li
Bing Zhao
Chi Xu
Yuan Liu
Haonan Li
Bingjie Zhang
Xinquan Wang
Xiao Yang
Wei Xie
Baojie Li
Jing-Dong Jackie Han
Ye-Guang Chen
BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes
description Bone morphogenetic protein (BMP) maintains intestinal homeostasis by restricting its hyperproliferation but whether it directly regulates the stem cells is unknown. Here the authors show that BMP constrains the Lgr5+stem cell expansion under both homeostatic and injury conditions through Smad-mediated repression of stem cell signature genes.
format article
author Zhen Qi
Yehua Li
Bing Zhao
Chi Xu
Yuan Liu
Haonan Li
Bingjie Zhang
Xinquan Wang
Xiao Yang
Wei Xie
Baojie Li
Jing-Dong Jackie Han
Ye-Guang Chen
author_facet Zhen Qi
Yehua Li
Bing Zhao
Chi Xu
Yuan Liu
Haonan Li
Bingjie Zhang
Xinquan Wang
Xiao Yang
Wei Xie
Baojie Li
Jing-Dong Jackie Han
Ye-Guang Chen
author_sort Zhen Qi
title BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes
title_short BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes
title_full BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes
title_fullStr BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes
title_full_unstemmed BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes
title_sort bmp restricts stemness of intestinal lgr5+ stem cells by directly suppressing their signature genes
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/1cfafbf39370423c97491755711f11d9
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