BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes

BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes

Bone morphogenetic protein (BMP) maintains intestinal homeostasis by restricting its hyperproliferation but whether it directly regulates the stem cells is unknown. Here the authors show that BMP constrains the Lgr5+stem cell expansion under both homeostatic and injury conditions through Smad-mediat...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Zhen Qi, Yehua Li, Bing Zhao, Chi Xu, Yuan Liu, Haonan Li, Bingjie Zhang, Xinquan Wang, Xiao Yang, Wei Xie, Baojie Li, Jing-Dong Jackie Han, Ye-Guang Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/1cfafbf39370423c97491755711f11d9
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares