BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes
Bone morphogenetic protein (BMP) maintains intestinal homeostasis by restricting its hyperproliferation but whether it directly regulates the stem cells is unknown. Here the authors show that BMP constrains the Lgr5+stem cell expansion under both homeostatic and injury conditions through Smad-mediat...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2017
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| Subjects: | |
| Online Access: | https://doaj.org/article/1cfafbf39370423c97491755711f11d9 |
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