Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

Modifying the non-ribosomal peptide synthase (NRPS)/polyketide synthase (PKS) pathway to generate novel non-ribosomal peptides often results in a loss of productivity. Here the authors use evolutionary alignments of NRPS/PKS gene clusters to guide rational design of complexes that can produce novel...

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Autores principales:	Takayoshi Awakawa, Takuma Fujioka, Lihan Zhang, Shotaro Hoshino, Zhijuan Hu, Junko Hashimoto, Ikuko Kozone, Haruo Ikeda, Kazuo Shin-Ya, Wen Liu, Ikuro Abe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/209bc4d1b5344a32b292f405caa6ac8b
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spelling	oai:doaj.org-article:209bc4d1b5344a32b292f405caa6ac8b2021-12-02T17:33:05ZReprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution10.1038/s41467-018-05877-z2041-1723https://doaj.org/article/209bc4d1b5344a32b292f405caa6ac8b2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05877-zhttps://doaj.org/toc/2041-1723Modifying the non-ribosomal peptide synthase (NRPS)/polyketide synthase (PKS) pathway to generate novel non-ribosomal peptides often results in a loss of productivity. Here the authors use evolutionary alignments of NRPS/PKS gene clusters to guide rational design of complexes that can produce novel lactones.Takayoshi AwakawaTakuma FujiokaLihan ZhangShotaro HoshinoZhijuan HuJunko HashimotoIkuko KozoneHaruo IkedaKazuo Shin-YaWen LiuIkuro AbeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takayoshi Awakawa Takuma Fujioka Lihan Zhang Shotaro Hoshino Zhijuan Hu Junko Hashimoto Ikuko Kozone Haruo Ikeda Kazuo Shin-Ya Wen Liu Ikuro Abe Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
description	Modifying the non-ribosomal peptide synthase (NRPS)/polyketide synthase (PKS) pathway to generate novel non-ribosomal peptides often results in a loss of productivity. Here the authors use evolutionary alignments of NRPS/PKS gene clusters to guide rational design of complexes that can produce novel lactones.
format	article
author	Takayoshi Awakawa Takuma Fujioka Lihan Zhang Shotaro Hoshino Zhijuan Hu Junko Hashimoto Ikuko Kozone Haruo Ikeda Kazuo Shin-Ya Wen Liu Ikuro Abe
author_facet	Takayoshi Awakawa Takuma Fujioka Lihan Zhang Shotaro Hoshino Zhijuan Hu Junko Hashimoto Ikuko Kozone Haruo Ikeda Kazuo Shin-Ya Wen Liu Ikuro Abe
author_sort	Takayoshi Awakawa
title	Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
title_short	Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
title_full	Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
title_fullStr	Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
title_full_unstemmed	Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
title_sort	reprogramming of the antimycin nrps-pks assembly lines inspired by gene evolution
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/209bc4d1b5344a32b292f405caa6ac8b
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Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

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