Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase

par Kei Kudo, Takehiro Nishimura, Ikuko Kozone, Junko Hashimoto, Noritaka Kagaya, Hikaru Suenaga, Haruo Ikeda, Kazuo Shin-ya
Publié 2021

Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo

par Taro Ozaki, Kona Yamashita, Yuki Goto, Morito Shimomura, Shohei Hayashi, Shumpei Asamizu, Yoshinori Sugai, Haruo Ikeda, Hiroaki Suga, Hiroyasu Onaka
Publié 2017

Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

par Takayoshi Awakawa, Takuma Fujioka, Lihan Zhang, Shotaro Hoshino, Zhijuan Hu, Junko Hashimoto, Ikuko Kozone, Haruo Ikeda, Kazuo Shin-Ya, Wen Liu, Ikuro Abe
Publié 2018

In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives

par Kei Kudo, Takuya Hashimoto, Junko Hashimoto, Ikuko Kozone, Noritaka Kagaya, Reiko Ueoka, Takehiro Nishimura, Mamoru Komatsu, Hikaru Suenaga, Haruo Ikeda, Kazuo Shin-ya
Publié 2020

Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host

par Keita Amagai, Haruo Ikeda, Junko Hashimoto, Ikuko Kozone, Miho Izumikawa, Fumitaka Kudo, Tadashi Eguchi, Takemichi Nakamura, Hiroyuki Osada, Shunji Takahashi, Kazuo Shin-ya
Publié 2017