MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance

MDC1 and H2AX interact and accumulate at sites of DNA damage, functioning to recruit additional factors involved in the repair process. Here the authors uncover a function for MDC1 that is independent of the presence of H2AX and is mediated through its PST-repeat region.

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Autores principales:	Israel Salguero, Rimma Belotserkovskaya, Julia Coates, Matylda Sczaniecka-Clift, Mukerrem Demir, Satpal Jhujh, Marcus D. Wilson, Stephen P. Jackson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/21117acef63244bb9e2d9e9cce4c5293
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spelling	oai:doaj.org-article:21117acef63244bb9e2d9e9cce4c52932021-12-02T17:01:32ZMDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance10.1038/s41467-019-12929-52041-1723https://doaj.org/article/21117acef63244bb9e2d9e9cce4c52932019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12929-5https://doaj.org/toc/2041-1723MDC1 and H2AX interact and accumulate at sites of DNA damage, functioning to recruit additional factors involved in the repair process. Here the authors uncover a function for MDC1 that is independent of the presence of H2AX and is mediated through its PST-repeat region.Israel SalgueroRimma BelotserkovskayaJulia CoatesMatylda Sczaniecka-CliftMukerrem DemirSatpal JhujhMarcus D. WilsonStephen P. JacksonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Israel Salguero Rimma Belotserkovskaya Julia Coates Matylda Sczaniecka-Clift Mukerrem Demir Satpal Jhujh Marcus D. Wilson Stephen P. Jackson MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance
description	MDC1 and H2AX interact and accumulate at sites of DNA damage, functioning to recruit additional factors involved in the repair process. Here the authors uncover a function for MDC1 that is independent of the presence of H2AX and is mediated through its PST-repeat region.
format	article
author	Israel Salguero Rimma Belotserkovskaya Julia Coates Matylda Sczaniecka-Clift Mukerrem Demir Satpal Jhujh Marcus D. Wilson Stephen P. Jackson
author_facet	Israel Salguero Rimma Belotserkovskaya Julia Coates Matylda Sczaniecka-Clift Mukerrem Demir Satpal Jhujh Marcus D. Wilson Stephen P. Jackson
author_sort	Israel Salguero
title	MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance
title_short	MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance
title_full	MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance
title_fullStr	MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance
title_full_unstemmed	MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance
title_sort	mdc1 pst-repeat region promotes histone h2ax-independent chromatin association and dna damage tolerance
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/21117acef63244bb9e2d9e9cce4c5293
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MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance

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