Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection
Influenza A infection results in γδ T cell influx and production of IL-17 in the lungs. Here, the authors show that this effect is primed by CD1-restricted ligands that are released by infected cells and presented by B1a cells in the lungs.
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Nature Portfolio
2021
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oai:doaj.org-article:232a7455244b4ab7a369fc9f8653e33a2021-12-02T16:35:53ZHost-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection10.1038/s41467-021-22242-92041-1723https://doaj.org/article/232a7455244b4ab7a369fc9f8653e33a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22242-9https://doaj.org/toc/2041-1723Influenza A infection results in γδ T cell influx and production of IL-17 in the lungs. Here, the authors show that this effect is primed by CD1-restricted ligands that are released by infected cells and presented by B1a cells in the lungs.Xiaohui WangXiang LinZihan ZhengBingtai LuJun WangAndy Hee-Meng TanMeng ZhaoJia Tong LohSze Wai NgQian ChenFan XiaoEnyu HuangKing-Hung KoZhong HuangJingyi LiKin-Hang KokGen LuXiaohui LiuKong-Peng LamWanli LiuYuxia ZhangKwok-Yung YuenTak Wah MakLiwei LuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Xiaohui Wang Xiang Lin Zihan Zheng Bingtai Lu Jun Wang Andy Hee-Meng Tan Meng Zhao Jia Tong Loh Sze Wai Ng Qian Chen Fan Xiao Enyu Huang King-Hung Ko Zhong Huang Jingyi Li Kin-Hang Kok Gen Lu Xiaohui Liu Kong-Peng Lam Wanli Liu Yuxia Zhang Kwok-Yung Yuen Tak Wah Mak Liwei Lu Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection |
| description |
Influenza A infection results in γδ T cell influx and production of IL-17 in the lungs. Here, the authors show that this effect is primed by CD1-restricted ligands that are released by infected cells and presented by B1a cells in the lungs. |
| format |
article |
| author |
Xiaohui Wang Xiang Lin Zihan Zheng Bingtai Lu Jun Wang Andy Hee-Meng Tan Meng Zhao Jia Tong Loh Sze Wai Ng Qian Chen Fan Xiao Enyu Huang King-Hung Ko Zhong Huang Jingyi Li Kin-Hang Kok Gen Lu Xiaohui Liu Kong-Peng Lam Wanli Liu Yuxia Zhang Kwok-Yung Yuen Tak Wah Mak Liwei Lu |
| author_facet |
Xiaohui Wang Xiang Lin Zihan Zheng Bingtai Lu Jun Wang Andy Hee-Meng Tan Meng Zhao Jia Tong Loh Sze Wai Ng Qian Chen Fan Xiao Enyu Huang King-Hung Ko Zhong Huang Jingyi Li Kin-Hang Kok Gen Lu Xiaohui Liu Kong-Peng Lam Wanli Liu Yuxia Zhang Kwok-Yung Yuen Tak Wah Mak Liwei Lu |
| author_sort |
Xiaohui Wang |
| title |
Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection |
| title_short |
Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection |
| title_full |
Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection |
| title_fullStr |
Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection |
| title_full_unstemmed |
Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection |
| title_sort |
host-derived lipids orchestrate pulmonary γδ t cell response to provide early protection against influenza virus infection |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/232a7455244b4ab7a369fc9f8653e33a |
| work_keys_str_mv |
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1718383680539328512 |