Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice

Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice

Mutation of the human genePHF8, encoding a histone demethylase, is linked to cognitive defects but its role in development is unclear. Here, the authors show that Phf8deletion in mice causes no overt developmental defects but confers resilience to depression, likely through increased serotonin signa...

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Bibliographic Details
Main Authors: Ryan M. Walsh, Erica Y. Shen, Rosemary C. Bagot, Anthony Anselmo, Yan Jiang, Behnam Javidfar, Gregory J. Wojtkiewicz, Jennifer Cloutier, John W. Chen, Ruslan Sadreyev, Eric J. Nestler, Schahram Akbarian, Konrad Hochedlinger
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
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Online Access:https://doaj.org/article/261ca9d8da8c4c53b1a7c7d577c757f8
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