A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

Gene expression and how genetic variants can influence gene expression are tissue-specific processes with important implications for phenotypes. Here, Richardson et al. use eQTL data from GTEx and the eQTLGen project in a two-sample SMR + HEIDI framework for causal inference of gene expression assoc...

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Autores principales: Tom G. Richardson, Gibran Hemani, Tom R. Gaunt, Caroline L. Relton, George Davey Smith
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/29f4249da2314cbd93d49efdc1ca8c68
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